ArticleGenetics2008
A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- The RNA-binding protein Swm is critical for Drosophila melanogaster intestinal progenitor cell maintenance.Genetics · 2022Article
- Review
- Hedgehog produced by theDevelopment (Cambridge, England) · 2020Article
- An Efficient Screen for Cell-Intrinsic Factors Identifies the Chaperonin CCT and Multiple Conserved Mechanisms as Mediating Dendrite Morphogenesis.Frontiers in cellular neuroscience · 2020Article
- Article
- The emerging roles of phosphatases in Hedgehog pathway.Cell communication and signaling : CCS · 2017Review
- Modeling congenital disease and inborn errors of development in Drosophila melanogaster.Disease models & mechanisms · 2016Review
- Smoothened regulation in response to Hedgehog stimulation.Frontiers in biology · 2015Article
- Apical accumulation of the Sevenless receptor tyrosine kinase during Drosophila eye development is promoted by the small GTPase Rap1.Genetics · 2014Article
- unfulfilled interacting genes display branch-specific roles in the development of mushroom body axons in Drosophila melanogaster.G3 (Bethesda, Md.) · 2014Article
- Microarray comparison of anterior and posterior Drosophila wing imaginal disc cells identifies novel wing genes.G3 (Bethesda, Md.) · 2013Article
- Sequential phosphorylation of smoothened transduces graded hedgehog signaling.Science signaling · 2011Article
- A novel interaction between hedgehog and Notch promotes proliferation at the anterior-posterior organizer of the Drosophila wing.Genetics · 2011Article
- Article
- In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling.PloS one · 2011Article
- Identification of genes required for neural-specific glycosylation using functional genomics.PLoS genetics · 2010Article
- PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation.Development (Cambridge, England) · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signaling by Hedgehog (Hh) proteins shapes most tissues and organs in both vertebrates and invertebrates, and its misregulation has been implicated in many human diseases. Although components of the signaling pathway have been identified, key aspects of the signaling mechanism and downstream targets remain to be elucidated. We performed an enhancer/suppressor screen in Drosophila to identify novel components of the pathway and identified 26 autosomal regions that modify a phenotypic readout of Hh signaling. Three of the regions include genes that contribute constituents to the pathway-patched, engrailed, and hh. One of the other regions includes the gene microtubule star (mts) that encodes a subunit of protein phosphatase 2A. We show that mts is necessary for full activation of Hh signaling. A second region includes the gene second mitotic wave missing (swm). swm is recessive lethal and is predicted to encode an evolutionarily conserved protein with RNA binding and Zn(+) finger domains. Characterization of newly isolated alleles indicates that swm is a negative regulator of Hh signaling and is essential for cell polarity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.