ArticleGenetics2008
The impact of dissociation on transposon-mediated disease control strategies.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Transformative Approaches for Sustainable Weed Management: The Power of Gene Drive and CRISPR-Cas9.Genes · 2023Review
- The cost-effectiveness of controlling dengue in Indonesia using wMel Wolbachia released at scale: a modelling study.BMC medicine · 2020Article
- Modeling the mutation and reversal of engineered underdominance gene drives.Journal of theoretical biology · 2019Article
- Dynamics of Transposable Element Invasions with piRNA Clusters.Molecular biology and evolution · 2019Article
- Population dynamics of engineered underdominance and killer-rescue gene drives in the control of disease vectors.PLoS computational biology · 2018Article
- Conditions for success of engineered underdominance gene drive systems.Journal of theoretical biology · 2017Article
- Evaluating paratransgenesis as a potential control strategy for African trypanosomiasis.PLoS neglected tropical diseases · 2013Article
- Confinement of gene drive systems to local populations: a comparative analysis.Journal of theoretical biology · 2012Article
- Engineering the genomes of wild insect populations: challenges, and opportunities provided by synthetic Medea selfish genetic elements.Journal of insect physiology · 2010Review
- Malaria control with transgenic mosquitoes.PLoS medicine · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Vector-borne diseases such as malaria and dengue fever continue to be a major health concern through much of the world. The emergence of chloroquine-resistant strains of malaria and insecticide-resistant mosquitoes emphasize the need for novel methods of disease control. Recently, there has been much interest in the use of transposable elements to drive resistance genes into vector populations as a means of disease control. One concern that must be addressed before a release is performed is the potential loss of linkage between a transposable element and a resistance gene. Transposable elements such as P and hobo have been shown to produce internal deletion derivatives at a significant rate, and there is concern that a similar process could lead to loss of the resistance gene from the drive system following a transgenic release. Additionally, transposable elements such as Himar1 have been shown to transpose significantly more frequently when free of exogenous DNA. Here, we show that any transposon-mediated gene drive strategy must have an exceptionally low rate of dissociation if it is to be effective. Additionally, the resistance gene must confer a large selective advantage to the vector to surmount the effects of a moderate dissociation rate and transpositional handicap.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.