ArticleGenetics2008
Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Functional test of a naturally occurred tumor modifier gene provides insights to melanoma development.G3 (Bethesda, Md.) · 2025Article
- Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice.Genetics · 2024Article
- Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus).Genetics · 2022Article
- Copy-number variation introduced by long transgenes compromises mouse male fertility independently of pachytene checkpoints.Chromosoma · 2020Article
- Mouse protein coding diversity: What's left to discover?PLoS genetics · 2019Review
- Gene Regulation and Speciation.Trends in genetics : TIG · 2017Review
- X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids.PLoS genetics · 2014Article
- Prdm9 incompatibility controls oligospermia and delayed fertility but no selfish transmission in mouse intersubspecific hybrids.PloS one · 2014Article
- The phenotypic distribution of quantitative traits in a wild mouse F1 population.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility.PLoS genetics · 2012Article
- Genetic dissection of a key reproductive barrier between nascent species of house mice.Genetics · 2011Article
- A novel strategy for genetic dissection of complex traits: the population of specific chromosome substitution strains from laboratory and wild mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Review
- Accelerated evolution of the Prdm9 speciation gene across diverse metazoan taxa.PLoS genetics · 2009Article
- Polymorphism in hybrid male sterility in wild-derived Mus musculus musculus strains on proximal chromosome 17.Mammalian genome : official journal of the International Mammalian Genome Society · 2009Article
- Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels.Genome biology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive linkage disequilibrium among classical laboratory strains represents an obstacle in the high-resolution haplotype mapping of mouse quantitative trait loci (QTL). To determine the potential of wild-derived mouse strains for fine QTL mapping, we constructed a haplotype map of a 250-kb region of the t-complex on chromosome 17 containing the Hybrid sterility 1 (Hst1) gene. We resequenced 33 loci from up to 80 chromosomes of five mouse (sub)species. Trans-species single-nucleotide polymorphisms (SNPs) were rare between Mus m. musculus (Mmmu) and Mus m. domesticus (Mmd). The haplotypes in Mmmu and Mmd differed and therefore strains from these subspecies should not be combined for haplotype-associated mapping. The haplotypes of t-chromosomes differed from all non-t Mmmu and Mmd haplotypes. Half of the SNPs and SN indels but only one of seven longer rearrangements found in classical laboratory strains were useful for haplotype mapping in the wild-derived M. m. domesticus. The largest Mmd haplotype block contained three genes of a highly conserved synteny. The lengths of the haplotype blocks deduced from 36 domesticus chromosomes were in tens of kilobases, suggesting that the wild-derived Mmd strains are suitable for fine interval-specific mapping.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.