ArticleGenetics2008
Selection in the making: a worldwide survey of haplotypic diversity around a causative mutation in porcine IGF2.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Signatures of Admixture and Genetic Uniqueness in the Autochthonous Greek Black Pig Breed Deduced from Gene Polymorphisms Affecting Domestication-Derived Traits.Animals : an open access journal from MDPI · 2023Article
- On the origins of American Criollo pigs: A common genetic background with a lasting Iberian signature.PloS one · 2021Article
- A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs.PLoS genetics · 2019Article
- Genome-wide SNP data unveils the globalization of domesticated pigs.Genetics, selection, evolution : GSE · 2017Article
- Article
- Artificial selection on introduced Asian haplotypes shaped the genetic architecture in European commercial pigs.Proceedings. Biological sciences · 2015Article
- Haplotypic diversity of porcine LEP and LEPR genes involved in growth and fatness regulation.Journal of applied genetics · 2015Article
- Genomic analysis reveals selection for Asian genes in European pigs following human-mediated introgression.Nature communications · 2014Article
- Identification of selection signatures in livestock species.Genetics and molecular biology · 2014Review
- Investigation of four candidate genes (IGF2, JHDM1A, COPB1 and TEF1) for growth rate and backfat thickness traits on SSC2q in Large White pigs.Molecular biology reports · 2014Article
- Hybrid origin of European commercial pigs examined by an in-depth haplotype analysis on chromosome 1.Frontiers in genetics · 2014Article
- Nucleotide variability and linkage disequilibrium patterns in the porcine MUC4 gene.BMC genetics · 2012Article
- The genetic structure of domestic rabbits.Molecular biology and evolution · 2011Article
- Number and mode of inheritance of QTL influencing backfat thickness on SSC2p in Sino-European pig pedigrees.Genetics, selection, evolution : GSE · 2011Article
- Article
- Article
- ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals.Transcription · 2010Article
- Non-additive effects of RBP4, ESR1 and IGF2 polymorphisms on litter size at different parities in a Chinese-European porcine line.Genetics, selection, evolution : GSE · 2010Article
- Genome-wide scans for footprints of natural selection.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Domestic species allow us to study dramatic evolutionary changes at an accelerated rate due to the effectiveness of modern breeding techniques and the availability of breeds that have undergone distinct selection pressures. We present a worldwide survey of haplotype variability around a known causative mutation in porcine gene IGF2, which increases lean content. We genotyped 34 SNPs spanning 27 kb in 237 domestic pigs and 162 wild boars. Although the selective process had wiped out variability for at least 27 kb in the haplotypes carrying the mutation, there was no indication of an overall reduction in genetic variability of international vs. European local breeds; there was also no evidence of a reduction in variability caused by domestication. The haplotype structure and a plot of Tajima's D against the frequency of the causative mutation across breeds suggested a temporal pattern, where each breed corresponded to a different selective stage. This was observed comparing the haplotype neighbor-joining (NJ) trees of breeds that have undergone increasing selection pressures for leanness, e.g., European local breeds vs. Pietrain. These results anticipate that comparing current domestic breeds will decisively help to recover the genetic history of domestication and contemporary selective processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.