ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2008
Pathways change in expression during replicative aging in Saccharomyces cerevisiae.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Transcriptional Reprogramming of Lifespan-Associated Genes in Yeast Lacking TOR1.Biochemical genetics · 2026Article
- Article
- Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespan.bioRxiv : the preprint server for biology · 2026Article
- Dynamic changes in gene expression through aging in Drosophila melanogaster heads.G3 (Bethesda, Md.) · 2025Article
- Dynamic Changes in Gene Expression Through Aging inbioRxiv : the preprint server for biology · 2024Article
- Senescence in yeast is associated with amplified linear fragments of chromosome XII rather than ribosomal DNA circle accumulation.PLoS biology · 2023Article
- Dietary change without caloric restriction maintains a youthful profile in ageing yeast.PLoS biology · 2023Article
- Article
- Proteasome Activator Blm10 Regulates Transcription Especially During Aging.Current genomics · 2021Article
- Ubiquitin Ligase Redundancy and Nuclear-Cytoplasmic Localization in Yeast Protein Quality Control.Biomolecules · 2021Review
- The Evolution of the Hallmarks of Aging.Frontiers in genetics · 2021Review
- Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging.Proteomics · 2020Review
- Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1.eLife · 2019Article
- Protein phosphatases of Saccharomyces cerevisiae.Current genetics · 2019Review
- Gene expression hallmarks of cellular ageing.Biogerontology · 2018Review
- Article
- Article
- Yeast as a tool to identify anti-aging compounds.FEMS yeast research · 2018Review
- Whi7 is an unstable cell-cycle repressor of the Start transcriptional program.Nature communications · 2017Article
- Evidence for the hallmarks of human aging in replicatively aging yeast.Microbial cell (Graz, Austria) · 2016Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors.
Funding
Abstract
Yeast replicative aging is a process resembling replicative aging in mammalian cells. During aging, wild-type haploid yeast cells enlarge, become sterile, and undergo nucleolar enlargement and fragmentation; we sought gene expression changes during the time of these phenotypic changes. Gene expression studied via microarrays and quantitative real-time reverse-transcription polymerase chain reaction (qPCR) has shown reproducible, statistically significant changes in messenger RNA (mRNA) of genes at 12 and 18-20 generations. Our findings support previously described changes towards aerobic metabolism, decreased ribosome gene expression, and a partial environmental stress response. Our findings include a pseudostationary phase, downregulation of methylation-related metabolism, increased nucleotide excision repair-related mRNA, and a strong upregulation of many of the regulatory subunits of protein phosphatase I (Glc7). These findings are correlated with aging changes in higher organisms as well as with the known involvement of protein phosphorylation states during yeast aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.