ArticleGenetics2008
Comparative genetics of sex determination: masculinizing mutations in Caenorhabditis briggsae.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Haldane's law works through X:Autosome incompatibility in Caenorhabditis briggsae/C. nigoni hybrids.Nature communications · 2026Article
- TheiScience · 2025Article
- Article
- Rewiring the Sex-Determination Pathway During the Evolution of Self-Fertility.Molecular biology and evolution · 2024Article
- Article
- Lagging X chromatids specify the orientation of asymmetric organelle partitioning in XX spermatocytes of Auanema rhodensis.Genetics · 2022Article
- Transcription factors regulating the fate and developmental potential of a multipotent progenitor in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
- Possible stochastic sex determination in Bursaphelenchus nematodes.Nature communications · 2022Article
- Sex Determination in Nematode Germ Cells.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022Review
- Widespread misregulation of inter-species hybrid transcriptomes due to sex-specific and sex-chromosome regulatory evolution.PLoS genetics · 2021Article
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- From "the Worm" to "the Worms" and Back Again: The Evolutionary Developmental Biology of Nematodes.Genetics · 2018Review
- Revisiting Suppression of Interspecies Hybrid Male Lethality inG3 (Bethesda, Md.) · 2017Article
- Dependence of the sperm/oocyte decision on the nucleosome remodeling factor complex was acquired during recent Caenorhabditis briggsae evolution.Molecular biology and evolution · 2014Article
- The same but different: worms reveal the pervasiveness of developmental system drift.PLoS genetics · 2014Article
- The evolutionary origins and consequences of self-fertility in nematodes.F1000prime reports · 2014Review
- Evolutionary change within a bipotential switch shaped the sperm/oocyte decision in hermaphroditic nematodes.PLoS genetics · 2013Article
- Genetic control of vulval development in Caenorhabditis briggsae.G3 (Bethesda, Md.) · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nematodes Caenorhabditis elegans and C. briggsae independently evolved self-fertile hermaphroditism from gonochoristic ancestors. C. briggsae has variably divergent orthologs of nearly all genes in the C. elegans sex determination pathway. Their functional characterization has generally relied on reverse genetic approaches, such as RNA interference and cross-species transgene rescue and more recently on deletion mutations. We have taken an unbiased forward mutagenesis approach to isolating zygotic mutations that masculinize all tissues of C. briggsae hermaphrodites. The screens identified loss-of-function mutations in the C. briggsae orthologs of tra-1, tra-2, and tra-3. The somatic and germline phenotypes of these mutations are largely identical to those of their C. elegans homologs, including the poorly understood germline feminization of tra-1(lf) males. This overall conservation of Cb-tra phenotypes is in contrast to the fem genes, with which they directly interact and which are significantly divergent in germline function. In addition, we show that in both C. briggsae and C. elegans large C-terminal truncations of TRA-1 that retain the DNA-binding domain affect sex determination more strongly than somatic gonad development. Beyond these immediate results, this collection of mutations provides an essential foundation for further comparative genetic analysis of the Caenorhabditis sex determination pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.