ArticleGenetics2008
Neuropathology in Drosophila mutants with increased seizure susceptibility.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 33 citations in OpenAlex.
- Loss of the NF-κB negative regulator Pirk inBrain communications · 2025Article
- Phosphatidylserine synthase plays an essential role in glia and affects development, as well as the maintenance of neuronal function.iScience · 2021Article
- Shortened Lifespan and Other Age-Related Defects in Bang Sensitive Mutants ofG3 (Bethesda, Md.) · 2018Article
- Lipid metabolic perturbation is an early-onset phenotype in adultMolecular biology of the cell · 2017Article
- The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif.Cell reports · 2015Article
- Article
- Death following traumatic brain injury in Drosophila is associated with intestinal barrier dysfunction.eLife · 2015Article
- Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.Neurobiology of disease · 2014Article
- The alternative oxidase AOX does not rescue the phenotype of tko25t mutant flies.G3 (Bethesda, Md.) · 2014Article
- SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration.Cell metabolism · 2014Article
- Rescue of easily shocked mutant seizure sensitivity in Drosophila adults.The Journal of comparative neurology · 2013Article
- The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila.PloS one · 2013Article
- A mutation in Drosophila Aldolase causes temperature-sensitive paralysis, shortened lifespan, and neurodegeneration.Journal of neurogenetics · 2012Article
- A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease.Brain and behavior · 2012Article
- Mechanical and temperature stressor-induced seizure-and-paralysis behaviors in Drosophila bang-sensitive mutants.Journal of neurogenetics · 2012Article
- Probing mechanisms that underlie human neurodegenerative diseases in Drosophila.Annual review of genetics · 2012Review
- Mutations in prickle orthologs cause seizures in flies, mice, and humans.American journal of human genetics · 2011Article
- Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction.PloS one · 2011Article
- Article
- Sialyltransferase regulates nervous system function in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Genetic factors are known to contribute to seizure susceptibility, although the long-term effects of these predisposing factors on neuronal viability remain unclear. To examine the consequences of genetic factors conferring increased seizure susceptibility, we surveyed a class of Drosophila mutants that exhibit seizures and paralysis following mechanical stimulation. These bang-sensitive seizure mutants exhibit shortened life spans and age-dependent neurodegeneration. Because the increased seizure susceptibility in these mutants likely results from altered metabolism and since the Na(+)/K(+) ATPase consumes the majority of ATP in neurons, we examined the effect of ATPalpha mutations in combination with bang-sensitive mutations. We found that double mutants exhibit strikingly reduced life spans and age-dependent uncoordination and inactivity. These results emphasize the importance of proper cellular metabolism in maintaining both the activity and viability of neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.