ArticleGenetics2008
A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- SPOC domain proteins in health and disease.Genes & development · 2023Review
- Patched-Related Is Required for Proper Development of EmbryonicFrontiers in neuroscience · 2022Article
- Ultraspiracle-independent anti-apoptotic function of ecdysone receptors is required for the survival of larval peptidergic neurons via suppression of grim expression in Drosophila melanogaster.Apoptosis : an international journal on programmed cell death · 2019Article
- Direct measurement of pervasive weak repression by microRNAs and their role at the network level.BMC genomics · 2018Article
- Shep regulatesDevelopment (Cambridge, England) · 2018Article
- Regulatory Mechanisms of Metamorphic Neuronal Remodeling Revealed Through a Genome-Wide Modifier Screen inGenetics · 2017Article
- A fly's view of neuronal remodeling.Wiley interdisciplinary reviews. Developmental biology · 2016Review
- As the fat flies: The dynamic lipid droplets of Drosophila embryos.Biochimica et biophysica acta · 2015Review
- Neuronal remodeling during metamorphosis is regulated by the alan shepard (shep) gene in Drosophila melanogaster.Genetics · 2014Article
- Insulin signaling regulates neurite growth during metamorphic neuronal remodeling.Biology open · 2014Article
- Novel isoforms of the transport regulator klar.PloS one · 2013Article
- Diverse in- and output polarities and high complexity of local synaptic and non-synaptic signaling within a chemically defined class of peptidergic Drosophila neurons.Frontiers in neural circuits · 2013Article
- Genetic analysis of ecdysis behavior in Drosophila reveals partially overlapping functions of two unrelated neuropeptides.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila.Genetics · 2012Article
- Temporally tuned neuronal differentiation supports the functional remodeling of a neuronal network in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons.Developmental biology · 2011Article
- Targeting the motor regulator Klar to lipid droplets.BMC cell biology · 2011Article
- The essential role of bursicon during Drosophila development.BMC developmental biology · 2010Article
- Adverse interactions between micro-RNAs and target genes from different species.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The normal functioning of neuroendocrine systems requires that many neuropeptidergic cells change, to alter transmitter identity and concentration, electrical properties, and cellular morphology in response to hormonal cues. During insect metamorphosis, a pulse of circulating steroids, ecdysteroids, governs the dramatic remodeling of larval neurons to serve adult-specific functions. To identify molecular mechanisms underlying metamorphic remodeling, we conducted a neuropeptidergic cell-targeted, gain-of-function genetic screen. We screened 6097 lines. Each line permitted Gal4-regulated transcription of flanking genes. A total of 58 lines, representing 51 loci, showed defects in neuropeptide-mediated developmental transitions (ecdysis or wing expansion) when crossed to the panneuropeptidergic Gal4 driver, 386Y-Gal4. In a secondary screen, we found 29 loci that produced wing expansion defects when crossed to a crustacean cardioactive peptide (CCAP)/bursicon neuron-specific Gal4 driver. At least 14 loci disrupted the formation or maintenance of adult-specific CCAP/bursicon cell projections during metamorphosis. These include components of the insulin and epidermal growth factor signaling pathways, an ecdysteroid-response gene, cabut, and an ubiquitin-specific protease gene, fat facets, with known functions in neuronal development. Several additional genes, including three micro-RNA loci and two factors related to signaling by Myb-like proto-oncogenes, have not previously been implicated in steroid signaling or neuronal remodeling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.