ArticleGenetics2008
Low levels of polymorphism in genes that control the activation of defense response in Arabidopsis thaliana.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 64 citations in OpenAlex.
- Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae.PLoS pathogens · 2023Article
- Genetic variation underlying differential ammonium and nitrate responses in Arabidopsis thaliana.The Plant cell · 2022Article
- Evolutionary systems biology reveals patterns of rice adaptation to drought-prone agro-ecosystems.The Plant cell · 2022Article
- Article
- Integration of multi-omics approaches for functional characterization of muscle related selective sweep genes in Nanchukmacdon.Scientific reports · 2021Article
- Convergent Loss of an EDS1/PAD4 Signaling Pathway in Several Plant Lineages Reveals Coevolved Components of Plant Immunity and Drought Response.The Plant cell · 2020Article
- Article
- Diversification of defensins and NLRs in Arabidopsis species by different evolutionary mechanisms.BMC evolutionary biology · 2017Article
- Quantitative Resistance: More Than Just Perception of a Pathogen.The Plant cell · 2017Review
- Distribution and haplotype diversity of WKS resistance genes in wild emmer wheat natural populations.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
- The evolution of ethylene signaling in plant chemical ecology.Journal of chemical ecology · 2014Review
- Sequence diversity in coding regions of candidate genes in the glycoalkaloid biosynthetic pathway of wild potato species.G3 (Bethesda, Md.) · 2013Article
- Article
- Evolution and variability of Solanum RanGAP2, a cofactor in the incompatible interaction between the resistance protein GPA2 and the Globodera pallida effector Gp-RBP-1.BMC evolutionary biology · 2013Article
- Genome-wide patterns of genetic variation in worldwide Arabidopsis thaliana accessions from the RegMap panel.Nature genetics · 2012Article
- Targets of selection in a disease resistance network in wild tomatoes.Molecular plant pathology · 2011Article
- Article
- Genomic analysis of QTLs and genes altering natural variation in stochastic noise.PLoS genetics · 2011Article
- Combining genome-wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana.PLoS biology · 2011Article
- An analysis of sequence variability in eight genes putatively involved in drought response in sunflower (Helianthus annuus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Plants use signaling pathways involving salicylic acid, jasmonic acid, and ethylene to defend against pathogen and herbivore attack. Many defense response genes involved in these signaling pathways have been characterized, but little is known about the selective pressures they experience. A representative set of 27 defense response genes were resequenced in a worldwide set of 96 Arabidopsis thaliana accessions, and patterns of single nucleotide polymorphisms (SNPs) were evaluated in relation to an empirical distribution of SNPs generated from either 876 fragments or 236 fragments with >400 bp coding sequence (this latter set was selected for comparisons with coding sequences) distributed across the genomes of the same set of accessions. Defense response genes have significantly fewer protein variants, display lower levels of nonsynonymous nucleotide diversity, and have fewer nonsynonymous segregating sites. The majority of defense response genes appear to be experiencing purifying selection, given the dearth of protein variation in this set of genes. Eight genes exhibit some evidence of partial selective sweeps or transient balancing selection. These results therefore provide a strong contrast to the high levels of balancing selection exhibited by genes at the upstream positions in these signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.