ArticleGenetics2008
The molecular basis of host adaptation in cactophilic Drosophila: molecular evolution of a glutathione S-transferase gene (GstD1) in Drosophila mojavensis.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 74 citations in OpenAlex.
- Transposable elements contribute to the evolution of host shift-related genes in cactophilicGenome research · 2026Article
- Olfactory variation among closely related cactophilic Drosophila species.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Diverse signatures of convergent evolution in cactus-associated yeasts.PLoS biology · 2024Article
- Diverse signatures of convergent evolution in cacti-associated yeasts.bioRxiv : the preprint server for biology · 2023Article
- Physiological and life history changes associated with seasonal adaptation in the cactophilic Drosophila mojavensis.Biology open · 2022Article
- Comparative transcriptomics between Drosophila mojavensis and D. arizonae reveals transgressive gene expression and underexpression of spermatogenesis-related genes in hybrid testes.Scientific reports · 2021Article
- Contributions of cis- and trans-Regulatory Evolution to Transcriptomic Divergence across Populations in the Drosophila mojavensis Larval Brain.Genome biology and evolution · 2020Article
- Behavioral and Transcriptional Response to Selection for Olfactory Behavior inG3 (Bethesda, Md.) · 2020Article
- Molecular Evolution of the Glutathione S-Transferase Family in the Bemisia tabaci Species Complex.Genome biology and evolution · 2020Article
- Genomic analysis of the four ecologically distinct cactus host populations of Drosophila mojavensis.BMC genomics · 2019Article
- Population Genomics of the Neotropical Brown Stink Bug,Frontiers in genetics · 2019Article
- Positive selection at sites of chemosensory genes is associated with the recent divergence and local ecological adaptation in cactophilic Drosophila.BMC evolutionary biology · 2018Article
- Behavioral evolution accompanying host shifts in cactophilicEcology and evolution · 2018Article
- Physiological and Evolutionary Changes in a Biological Control Agent During Prey Shifts Over Several Generations.Frontiers in physiology · 2018Article
- Evolution of GSTD1 in Cactophilic Drosophila.Journal of molecular evolution · 2017Article
- Effects of temperature on transcriptome and cuticular hydrocarbon expression in ecologically differentiated populations of desertEcology and evolution · 2017Article
- Variation in life history traits and transcriptome associated with adaptation to diet shifts in the ladybird Cryptolaemus montrouzieri.BMC genomics · 2016Article
- Deciphering life history transcriptomes in different environments.Molecular ecology · 2015Article
- Evolution in an ancient detoxification pathway is coupled with a transition to herbivory in the drosophilidae.Molecular biology and evolution · 2014Article
- Article
Corrections and comments
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1 author at 1 institution in 1 country.
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Abstract
Drosophila mojavensis is a cactophilic fly endemic to the northwestern deserts of North America. This species includes four genetically isolated cactus host races each individually specializing on the necrotic tissues of a different cactus species. The necrosis of each cactus species provides the resident D. mojavensis populations with a distinct chemical environment. A previous investigation of the role of transcriptional variation in the adaptation of D. mojavensis to its hosts produced a set of candidate loci that are differentially expressed in response to host shifts, and among them was glutathione S-transferase D1 (GstD1). In both D. melanogaster and Anopheles gambiae, GstD1 has been implicated in the resistance of these species to the insecticide dichloro-diphenyl-trichloroethane (DDT). The pattern of sequence variation of the GstD1 locus from all four D. mojavensis populations, D. arizonae (sister species), and D. navojoa (outgroup) has been examined. The data suggest that in two populations of D. mojavensis GstD1 has gone through a period of adaptive amino acid evolution. Further analyses indicate that of the seven amino acid fixations that occurred in the D. mojavensis lineage, two of them occur in the active site pocket, potentially having a significant effect on substrate specificity and in the adaptation to alternative cactus hosts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.