ArticleGenetics2008
Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Burst of aneuploidy: a cost of adaptation driven by breakdown of cell cycle control.Molecular systems biology · 2026Article
- Autophagy-related protein Atg11 is essential for microtubule-mediated chromosome segregation.PLoS biology · 2025Article
- Parallel laboratory evolution and rational debugging reveal genomic plasticity toCell genomics · 2023Article
- Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation inmicroPublication biology · 2022Article
- Rapid Colorimetric Detection of Genome Evolution in SCRaMbLEd SyntheticMicroorganisms · 2020Article
- Single-Gene Deletions Contributing to Loss of Heterozygosity inG3 (Bethesda, Md.) · 2019Article
- Mutations in the S-Adenosylmethionine Synthetase GenesGenetics · 2019Article
- Article
- Single-Cell Based Quantitative Assay of Chromosome Transmission Fidelity.G3 (Bethesda, Md.) · 2015Article
- A FACS-optimized screen identifies regulators of genome stability in Candida albicans.Eukaryotic cell · 2015Article
- Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts.Nucleic acids research · 2013Article
- Genome-wide haploinsufficiency screen reveals a novel role for γ-TuSC in spindle organization and genome stability.Molecular biology of the cell · 2013Article
- RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.EMBO reports · 2012Article
- Article
- Cohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomes.PLoS genetics · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current techniques for identifying mutations that convey a small increased cancer risk or those that modify cancer risk in carriers of highly penetrant mutations are limited by the statistical power of epidemiologic studies, which require screening of large populations and candidate genes. To identify dosage-sensitive genes that mediate genomic stability, we performed a genomewide screen in Saccharomyces cerevisiae for heterozygous mutations that increase chromosome instability in a checkpoint-deficient diploid strain. We used two genome stability assays sensitive enough to detect the impact of heterozygous mutations and identified 172 heterozygous gene disruptions that affected chromosome fragment (CF) loss, 45% of which also conferred modest but statistically significant instability of endogenous chromosomes. Analysis of heterozygous deletion of 65 of these genes demonstrated that the majority increased genomic instability in both checkpoint-deficient and wild-type backgrounds. Strains heterozygous for COMA kinetochore complex genes were particularly unstable. Over 50% of the genes identified in this screen have putative human homologs, including CHEK2, ERCC4, and TOPBP1, which are already associated with inherited cancer susceptibility. These findings encourage the incorporation of this orthologous gene list into cancer epidemiology studies and suggest further analysis of heterozygous phenotypes in yeast as models of human disease resulting from haplo-insufficiency.
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