ArticleEukaryotic cell2008
Mating type protein Mat1-2 from asexual Aspergillus fumigatus drives sexual reproduction in fertile Aspergillus nidulans.
Article in Eukaryotic cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- UvPomt, an O-Methyltransferase Interacting with UvMAT1-1-3, for Regulating Growth, Stress Tolerance, and Virulence inJournal of fungi (Basel, Switzerland) · 2025Article
- Research Progress in Mutagenesis Techniques forMini reviews in medicinal chemistry · 2025Review
- Genomic Epidemiology Identifies Azole Resistance Due to TRJournal of fungi (Basel, Switzerland) · 2023Article
- Homeobox transcription factor HbxA influences expression of over one thousand genes in the model fungus Aspergillus nidulans.PloS one · 2023Article
- Long Terminal Repeat RetrotransposonAntimicrobial agents and chemotherapy · 2021Article
- The fungal sexual revolution continues: discovery of sexual development in members of the genus Aspergillus and its consequences.Fungal biology and biotechnology · 2020Article
- Global Sexual Fertility in the Opportunistic PathogenJournal of fungi (Basel, Switzerland) · 2020Article
- Evolution of asexual and sexual reproduction in the aspergilli.Studies in mycology · 2018Article
- Mating-type genes of the anamorphic fungus Ulocladium botrytis affect both asexual sporulation and sexual reproduction.Scientific reports · 2017Article
- Sex and the Imperfect Fungi.Microbiology spectrum · 2017Review
- Aspergillus: sex and recombination.Mycopathologia · 2014Review
- Structural and functional conservation of fungal MatA and human SRY sex-determining proteins.Nature communications · 2014Article
- The cryptic sexual strategies of human fungal pathogens.Nature reviews. Microbiology · 2014Review
- Article
- VeA regulates conidiation, gliotoxin production, and protease activity in the opportunistic human pathogen Aspergillus fumigatus.Eukaryotic cell · 2012Article
- Presence and functionality of mating type genes in the supposedly asexual filamentous fungus Aspergillus oryzae.Applied and environmental microbiology · 2012Article
- Article
- Complex mechanisms regulate developmental expression of the matA (HMG) mating type gene in homothallic Aspergillus nidulans.Genetics · 2011Article
- Evolution of eukaryotic microbial pathogens via covert sexual reproduction.Cell host & microbe · 2010Review
- Functional characterization of MAT1-1-specific mating-type genes in the homothallic ascomycete Sordaria macrospora provides new insights into essential and nonessential sexual regulators.Eukaryotic cell · 2010Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
The lack of an experimentally amenable sexual genetic system in Aspergillus fumigatus is a major limitation in the study of the organism's pathogenesis. A recent comparative genome analysis revealed evidence for potential sexuality in A. fumigatus. Homologs of mating type genes as well as other genes of the "sexual machinery" have been identified in anamorphic A. fumigatus. The mat1-2 gene encodes a homolog of MatA, an HMG box mating transcriptional factor (Mat(HMG)) that regulates sexual development in fertile Aspergillus nidulans. In this study, the functionalities of A. fumigatus mat1-2 and the Mat1-2 protein were determined by interspecies gene exchange between sterile A. fumigatus and fertile A. nidulans. Ectopically integrated A. fumigatus mat1-2 (driven by its own promoter) was not functional in a sterile A. nidulans Delta matA strain, and no sexual development was observed. In contrast, the A. fumigatus mat1-2 open reading frame driven by the A. nidulans matA promoter and integrated by homologous gene replacement at the matA locus was functional and conferred full fertility. This is the first report showing that cross species mating type gene exchange between closely related Ascomycetes did not function in sexual development. This is also the first report demonstrating that a Mat(HMG) protein from an asexual species is fully functional, with viable ascospore differentiation, in a fertile homothallic species. The expression of mat1-2 was assessed in A. fumigatus and A. nidulans. Our data suggest that mat1-2 may not be properly regulated to allow sexuality in A. fumigatus. This study provides new insights about A. fumigatus asexuality and also suggests the possibility for the development of an experimentally amenable sexual cycle.
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