ArticleAmerican journal of respiratory and critical care medicine2008
Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans.
Article in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00021840 (Genetic Epidemiology of Asthma in Costa Rica), which is not on this map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Asthma in Costa Rica
Who cites it
43 citing papers in PubMed, 74 citations in OpenAlex.
- Associations of APOE variants with sphingomyelin and cholesterol metabolites across the life-course in diverse populations.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Sex differences in asthma: omics evidence and future directions.Frontiers in genetics · 2025Review
- From gene identifications to therapeutic targets for asthma: Focus on great potentials ofChinese medical journal pulmonary and critical care medicine · 2023Review
- Zinc finger protein 33B demonstrates sex interaction with atopy-related markers in childhood asthma.The European respiratory journal · 2023Article
- A unifying framework for rare variant association testing in family-based designs, including higher criticism approaches, SKATs, and burden tests.Bioinformatics (Oxford, England) · 2021Article
- A novel locus for exertional dyspnoea in childhood asthma.The European respiratory journal · 2021Article
- Pharmacometabolomics of Bronchodilator Response in Asthma and the Role of Age-Metabolite Interactions.Metabolites · 2019Article
- Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Expression and Regulation of Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin Receptor Heterocomplex in the Innate-Adaptive Immunity of Pediatric Asthma.International journal of molecular sciences · 2018Review
- Cockroach allergen exposure and risk of asthma.Allergy · 2016Review
- Thymic stromal lymphopoietin (TSLP) secretion from human nasal epithelium is a function of TSLP genotype.Mucosal immunology · 2015Article
- Genetic determinants in the development of sensitization to environmental allergens in early childhood.Immunity, inflammation and disease · 2014Article
- Asthma in Hispanics. An 8-year update.American journal of respiratory and critical care medicine · 2014Review
- Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: the Genes-environments and Admixture in Latino Asthmatics (GALA II) study.The Journal of allergy and clinical immunology · 2013Article
- MicroRNA-375 regulation of thymic stromal lymphopoietin by diesel exhaust particles and ambient particulate matter in human bronchial epithelial cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Relation between objective measures of atopy and myocardial infarction in the United States.The Journal of allergy and clinical immunology · 2013Article
- Single nucleotide polymorphisms in thymic stromal lymphopoietin gene are not associated with allergic rhinitis susceptibility in Chinese subjects.BMC medical genetics · 2012Article
- Article
- Functions of thymic stromal lymphopoietin in immunity and disease.Immunologic research · 2012Review
- Cellular and molecular mechanisms of TSLP function in human allergic disorders--TSLP programs the "Th2 code" in dendritic cells.Allergology international : official journal of the Japanese Society of Allergology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 3 countries.
Funding
Abstract
rationaleThe basis for gender influences on allergen-specific IgEs is unclear.
objectivesTo perform regular and sex-stratified genomewide linkage analyses of IgE to each of three allergens (Ascaris lumbricoides, Blatella germanica [German cockroach]), and Dermatophagoides pteronyssinus [dust mite]) and to conduct an association study of a candidate gene in a linked genomic region.
methodsGenomewide linkage analyses of allergen-specific IgEs were conducted in 653 members of eight large families of Costa Rican children with asthma. An analysis of the association between single-nucleotide polymorphisms in thymic stromal lymphopoietin (TSLP) and IgE measurements was conducted in 417 parent-child trios in Costa Rica. Significant results were replicated in 470 families of white children in the Childhood Asthma Management Program (CAMP). MEASUREMENTS AND MAIN
resultsAmong all subjects, there was suggestive evidence of linkage (LOD >/= 2.72) to IgE to Ascaris (on chromosome 7q) and IgE to dust mite (on chromosomes 7p and 12q). In a sex-stratified analysis, there was significant evidence of linkage to IgE to cockroach on chromosome 5q23 (peak LOD, 4.14 at 127 cM) in female subjects. TSLP is located within the 1.5 LOD-unit support interval for this linkage peak and has female-specific effects on lung disease in mice. In a sex-stratified analysis, the T allele of single-nucleotide polymorphism rs2289276 in TSLP was associated with reductions in IgE to cockroach (in Costa Rican girls) and total IgE (in girls in Costa Rica and in CAMP; P value for sex-by-genotype interaction, <0.01 in both studies).
conclusionsConsistent with findings in murine models, a variant in TSLP may have female-specific effects on allergic phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.