Evidence map›Paper›PMID 18243661›Full record

ReviewJournal of autoimmunity2008

Hunt for pluripotent stem cell -- regenerative medicine search for almighty cell.

Mariusz Z Ratajczak, Ewa K Zuba-Surma, Marcin Wysoczynski, Wu Wan, Janina Ratajczak, Wojciech Wojakowski, Magda Kucia

Open access · greenAbstract readReview
In one paragraph

Review in Journal of autoimmunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 100 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Stem cells in clinical dentistry.Journal of the American Dental Association (1939) · 2023
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Cancer stem cells and cell size: A causal link?Seminars in cancer biology · 2015
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Links between growth hormone and aging.Endokrynologia Polska · 2013
    Review
  17. Review
  18. Review
  19. Review
  20. Role of heat shock proteins in stem cell behavior.Progress in molecular biology and translational science · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mariusz Z RatajczakStem Cell Institute, James Graham Brown Cancer Center, University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA. mzrata01@louisville.edu
Ewa K Zuba-Surma
Marcin Wysoczynski
Wu Wan
Janina Ratajczak
Wojciech Wojakowski
Magda Kucia
University of Louisville · USJames Graham Brown Foundation · USMedical University of Silesia · PL

Funding

Novel mechanisms involving complement cascade in stem cell traffickingR01DK074720 · NIDDK · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2007 to 2020
$4.1M
The CXCR4-SDF-1 Axis in Metastatic RhabdomyosarcomaR01CA106281 · NCI · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2005 to 2009
$1.3M
NCI NIH HHS R01 CA106281NIDDK NIH HHS R01 DK074720
6 · The paper itself

Abstract

Regenerative medicine and tissue engineering are searching for a novel stem cell based therapeutic strategy that will allow for efficient treatment or even potential replacement of damaged organs. The pluripotent stem cell (PSC), which gives rise to cells from all three germ lineages, seems to be the most ideal candidate for such therapies. PSC could be extracted from developing embryos. However, since this source of stem cells for potential therapeutic purposes remains controversial, stem cell researchers look for PSC that could be isolated from the adult tissues or generated from already differentiated cells. True PSC should possess both potential for multilineage differentiation in vitro and, more importantly, also be able to complement in vivo blastocyst development. This review will summarize current approaches and limitations to isolate PSC from adult tissues or, alternatively, to generate it by nuclear reprogramming from already differentiated somatic cells.

Indexed as

Pluripotent Stem CellsAdultAnimalsCell DifferentiationCell LineageCell SeparationCellular ReprogrammingEmbryonic Stem CellsHematopoietic Stem CellsHumansMesenchymal Stem CellsMultipotent Stem CellsRegenerative MedicineStem Cell TransplantationTotipotent Stem Cells

Identifiers

PMID18243661
PMCPMC2692479
OpenAlexW2109210816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.