Evidence map›Paper›PMID 18243585›Full record

Trial reportDrug and alcohol dependence2008

A randomized trial of 6-month methadone maintenance with standard or minimal counseling versus 21-day methadone detoxification.

Valerie A Gruber, Kevin L Delucchi, Anousheh Kielstein, Steven L Batki

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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  5. Pharmacological therapies for management of opium withdrawal.The Cochrane database of systematic reviews · 2018
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  6. Methadone at tapered doses for the management of opioid withdrawal.The Cochrane database of systematic reviews · 2013
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Valerie A GruberDepartment of Psychiatry, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, Ward 93, San Francisco, CA 94110, USA. Valerie.Gruber@sfdph.org
Kevin L Delucchi
Anousheh Kielstein
Steven L Batki
University of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

TREATMENTS FOR COMPLEX PATIENTS IN NEW SETTINGSP50DA009253 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PROCHASKA, JUDITH J. · 1994 to 2014
$28.2M
TUBERCULOSIS CHEMOPROPHYLAXIS IN INJECTION DRUG USERSR01DA008526 · NIDA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BATKI, STEVEN L · 1994 to 1996
–
NIDA NIH HHS P50 DA009253NIDA NIH HHS P50 DA09253NIDA NIH HHS R01 DA008526NIDA NIH HHS R01 DA08526
6 · The paper itself

Abstract

backgroundImportant questions remain regarding the necessary duration and intensity for methadone treatment to be effective.

methodsAs part of a clinical trial of tuberculosis chemoprophylaxis [Batki, S.L., Gruber, V.A., Bradley, J.M., Bradley, M., Delucchi, K., 2002. A controlled trial of methadone treatment combined with directly observed isoniazid for tuberculosis prevention in injection drug users. Drug Alcohol Depend. 66 283-293. doi:10.1016/S0376-8716(01)00208-3], patients with opioid dependence were recruited from an outpatient 21-day methadone detoxification program and were randomly assigned to one of three treatment conditions: (1) continuation in 21-day methadone detoxification; (2) transfer to 6-month methadone maintenance with only minimal counseling; or (3) transfer to 6-month methadone maintenance with standard twice monthly counseling and as-needed social work and psychiatric services. Both the 6-month maintenance treatments were followed by 1.5 months of detoxification. Urine drug tests and self-report measures were collected at baseline, months 1-6, and month 8.5.

resultsCompared to 21-day methadone detoxification, 6-month methadone maintenance with either minimal or standard counseling resulted in fewer opiate positive urine tests and days of self-reported heroin and alcohol use. There was no change in cocaine use or other outcome measures. The increased counseling available in the standard counseling condition did not appear to reduce heroin use further than the minimal counseling condition, in contrast to the effect found for more structured counseling in long-term methadone maintenance (McLellan et al., 1993).

conclusionsSix months of methadone maintenance, even with minimal counseling, reduces heroin and alcohol use more than 21-day methadone detoxification.

Indexed as

AdultCounselingDemographyDrug Administration ScheduleFemaleHeroin DependenceHumansInactivation, MetabolicMaleMethadoneNarcoticsTime FactorsMethadoneNarcotics

Identifiers

PMID18243585
PMCPMC2821580
OpenAlexW1977988060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.