ArticleBiochemical and biophysical research communications2008
Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Variation analysis using random forests reveals domestication patterns and breeding trends in sugar beet.iScience · 2025Article
- The role of the adenylate kinase 5 gene in various diseases and cancer.Journal of clinical and translational science · 2024Review
- Kinetic and data-driven modeling of pancreatic β-cell central carbon metabolism and insulin secretion.PLoS computational biology · 2022Article
- Assessing the Interactions of Statins with Human Adenylate Kinase Isoenzyme 1: Fluorescence and Enzyme Kinetic Studies.International journal of molecular sciences · 2021Article
- Re-evaluation of Diadenosine Tetraphosphate (ApFrontiers in molecular biosciences · 2020Review
- Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed.Frontiers in genetics · 2019Article
- Changes in the cerebral phosphotransfer network impair energetic homeostasis in an aflatoxin BFish physiology and biochemistry · 2018Article
- Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic β-cell function.The EMBO journal · 2015Article
- AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels.Journal of bioenergetics and biomembranes · 2013Article
- Identification and biochemical characterization of adenylate kinase 1 from Clonorchis sinensis.Parasitology research · 2013Article
- K(ATP) channelopathies in the pancreas.Pflugers Archiv : European journal of physiology · 2010Review
- Adenylate kinase and AMP signaling networks: metabolic monitoring, signal communication and body energy sensing.International journal of molecular sciences · 2009Review
- Metabolic syndrome induces changes in KATP-channels and calcium currents in pancreatic β-cells.IsletsArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The role of adenylate kinase (AK) as a determinant of K-ATP channel activity in human pancreatic beta-cells was investigated. We have identified that two cytosolic isoforms of AK, AK1 and AK5 are expressed in human islets and INS-1 cells. Elevated concentrations of glucose inhibit AK1 expression and AK1 immunoprecipitates with the Kir6.2 subunit of K-ATP. AK activation by ATP+AMP stimulates K-ATP channel activity and this stimulation is abolished by AK inhibitors. We propose that glucose stimulation of beta-cells inhibits AK through glycolysis and also through the elevation of diadenosine polyphosphate levels. Glucose-dependent inhibition of AK increases the ATP/ADP ratio in the microenvironment of the K-ATP channel promoting channel closure and insulin secretion. The down-regulation of AK1 expression by hyperglycemia may contribute to the defective coupling of glucose metabolism to K-ATP channel activity in type 2 diabetes.
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