Linking differential chromatin loops to transcriptional decisions.

Effie Apostolou, Dimitris Thanos

Abstract readComment

In one paragraph

Article in Molecular cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus.Immunity · 2009
Article
Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling.The Journal of biological chemistry · 2009
Article

4 · The record

Corrections and comments

Comment on
Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus.2008

5 · Who and what money

Authors and funding

2 authors.

Effie ApostolouInstitute of Molecular Biology, Genetics and Biotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Efesiou Street, Athens, Greece.

Dimitris Thanos

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

GATA-1 and GATA-2 control proliferation and differentiation of hematopoietic progenitor cells via transcriptional regulation. In this issue of Molecular Cell, Jing et al. (2008) demonstrate that GATA factor exchange on the Kit locus directs a transcriptional switch by reconfiguring chromatin loops.

Indexed as

AnimalsCell LineChromatinChromatin Assembly and DisassemblyEnhancer Elements, GeneticErythropoiesisGATA1 Transcription FactorGATA2 Transcription FactorGene SilencingMiceNuclear ProteinsProto-Oncogene Proteins c-kitQuantitative Trait LociResponse ElementsTranscription FactorsChromatinGata1 protein, mouseGATA1 Transcription FactorGata2 protein, mouseGATA2 Transcription FactorNuclear ProteinsProto-Oncogene Proteins c-kitTranscription FactorsZfpm1 protein, mouse

Identifiers

PMID18243110

DOI10.1016/j.molcel.2008.01.008

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.