ArticleCell2008
NFATc1 balances quiescence and proliferation of skin stem cells.
Article in Cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 247 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
247 citing papers in PubMed, 422 citations in OpenAlex.
- Shelterin TPP1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells.Aging cell · 2026Article
- Identification of the MRTFA/SRF pathway as a critical regulator of quiescence and chemotherapy resistance in cancer.Cancer letters · 2026Article
- An updated guide to hair follicle stem cell markers and changes in their expression with aging.JID innovations : skin science from molecules to population health · 2026Review
- Nitrogen-Boosted HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Transcriptional and epigenetic mechanisms governing epidermal stem cell regulation.Frontiers in cell and developmental biology · 2026Review
- H2AK119ub dynamics control hair follicle stem cell quiescence.Nature communications · 2025Article
- Studying Hair Growth in Mice: Synchronization of Hair Follicle Growth by Depilation.Methods in molecular biology (Clifton, N.J.) · 2025Article
- PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence.Science advances · 2025Article
- Sphingolipid metabolism orchestrates establishment of the hair follicle stem cell compartment.The Journal of cell biology · 2025Article
- Real-World Assessment of Trilaciclib for the Prevention of Chemoradiotherapy-Induced Myelosuppression in Esophageal Squamous Cell Carcinoma: A Propensity Score Matching Study.Cancer medicine · 2025Article
- Investigation the role of SIRT3, SIRT7, NFATC1, and PDL-1 genes in androgenetic alopecia.BMC research notes · 2024Article
- Review
- Ontogeny of Skin Stem Cells and Molecular Underpinnings.Current issues in molecular biology · 2024Review
- Dab2 (Disabled-2), an adaptor protein, regulates self-renewal of hair follicle stem cells.Communications biology · 2024Article
- Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices.Science (New York, N.Y.) · 2024Article
- Recent progress in hair follicle stem cell markers and their regulatory roles.World journal of stem cells · 2024Review
- Regulation of long-range BMP gradients and embryonic polarity by propagation of local calcium-firing activity.Nature communications · 2024Article
- Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration.Experimental & molecular medicine · 2024Review
- Local and systemic mechanisms that control the hair follicle stem cell niche.Nature reviews. Molecular cell biology · 2024Review
- Cyclosporine-induced alopecia:a case report, FDA adverse event reporting system analysis and literature assessment.Frontiers in pharmacology · 2024Article
187 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Quiescent adult stem cells reside in specialized niches where they become activated to proliferate and differentiate during tissue homeostasis and injury. How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP signaling upstream and it acts downstream to transcriptionally repress CDK4 and maintain stem cell quiescence. As stem cells become activated during hair growth, NFATc1 is downregulated, relieving CDK4 repression and activating proliferation. When calcineurin/NFATc1 signaling is suppressed, pharmacologically or via complete or conditional NFATc1 gene ablation, stem cells are activated prematurely, resulting in precocious follicular growth. Our findings may explain why patients receiving cyclosporine A for immunosuppressive therapy display excessive hair growth, and unveil a functional role for calcium-NFATc1-CDK4 circuitry in governing stem cell quiescence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.