Trial reportBiological psychiatry2008
Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans.
Trial report in Biological psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02628054 (Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers), which is not on this map. Cited by 193 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Effects of Typhoid Vaccine on Sleep in Healthy Volunteers
Who cites it
193 citing papers in PubMed, 2 syntheses or guidelines pooled it, 382 citations in OpenAlex.
- Predictors of successful anti-inflammatory drug trials in patients with schizophrenia: A meta-regression and critical commentary.Brain, behavior, and immunity · 2023Pooled it
- Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies.Neuroscience and biobehavioral reviews · 2018Pooled it
- Effects of a mild inflammatory challenge on cytokines and sickness behavior: A randomized controlled trial using the influenza vaccine.Brain, behavior, and immunity · 2025Trial
- The Effects of Neuroinflammation Induced by Typhoid Vaccine on Resting and Task-Based Electroencephalography.Brain and behavior · 2025Trial
- Inflamed but not impulsive: Acute inflammatory cytokine response does not impact prepotent response inhibition.Journal of affective disorders · 2023Trial
- Effects of acute systemic inflammation on the interplay between sad mood and affective cognition.Translational psychiatry · 2017Trial
- Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Trial
- Effects of typhoid vaccine on inflammation and sleep in healthy participants: a double-blind, placebo-controlled, crossover study.Psychopharmacology · 2016Trial
- Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations.PloS one · 2016Trial
- Inflammation impairs social cognitive processing: A randomized controlled trial of endotoxin.Brain, behavior, and immunity · 2015Trial
- Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Peripheral inflammation acutely impairs human spatial memory via actions on medial temporal lobe glucose metabolism.Biological psychiatry · 2014Trial
- Infection hospitalization increases risk of dementia in the elderly.Critical care medicine · 2014Trial
- Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.PloS one · 2014Trial
- Central autonomic network mediates cardiovascular responses to acute inflammation: relevance to increased cardiovascular risk in depression?Brain, behavior, and immunity · 2013Trial
- A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers.JAMA psychiatry · 2013Trial
- Glucose metabolism in the insula and cingulate is affected by systemic inflammation in humans.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2012Trial
- Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity.Biological psychiatry · 2009Trial
- Neural origins of human sickness in interoceptive responses to inflammation.Biological psychiatry · 2009Trial
- An fMRI study of cytokine-induced depressed mood and social pain: the role of sex differences.NeuroImage · 2009Trial
133 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSystemic infections commonly cause sickness symptoms including psychomotor retardation. Inflammatory cytokines released during the innate immune response are implicated in the communication of peripheral inflammatory signals to the brain.
methodsWe used functional magnetic resonance brain imaging (fMRI) to investigate neural effects of peripheral inflammation following typhoid vaccination in 16 healthy men, using a double-blind, randomized, crossover-controlled design.
resultsVaccination had no global effect on neurovascular coupling but markedly perturbed neural reactivity within substantia nigra during low-level visual stimulation. During a cognitive task, individuals in whom typhoid vaccination engendered higher levels of circulating interleukin-6 had significantly slower reaction time responses. Prolonged reaction times and larger interleukin-6 responses were associated with evoked neural activity within substantia nigra.
conclusionsOur findings provide mechanistic insights into the interaction between inflammation and neurocognitive performance, specifically implicating circulating cytokines and midbrain dopaminergic nuclei in mediating the psychomotor consequences of systemic infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.