Evidence map›Paper›PMID 18242556›Full record

ArticleHeart rhythm2008

Antiarrhythmic effects of beta3-adrenergic receptor stimulation in a canine model of ventricular tachycardia.

Shengmei Zhou, Alex Y Tan, Offir Paz, Masahiro Ogawa, Chung-Chuan Chou, Hideki Hayashi, Motoki Nihei, Michael C Fishbein, Lan S Chen, Shien-Fong Lin and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heart rhythm, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. β(3) Receptors: Role in Cardiometabolic Disorders.Therapeutic advances in endocrinology and metabolism · 2011
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shengmei ZhouDivision of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Alex Y Tan
Offir Paz
Masahiro Ogawa
Chung-Chuan Chou
Hideki Hayashi
Motoki Nihei
Michael C Fishbein
Lan S Chen
Shien-Fong Lin
Peng-Sheng Chen
Cedars-Sinai Medical Center · USIndiana University – Purdue University Indianapolis · USUniversity of California, Los Angeles · US

Funding

WAVE DYNAMICS IN NORMAL AND DISEASED RABBIT HEARTSP01HL078931 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, JAMES · 2005 to 2015
$20.7M
Thoracic Veins and Sustained Atrial FibrillationR01HL071140 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHEN, PENG-SHENG · 2002 to 2014
$4.7M
Fibrillation and DefibrillationR01HL078932 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI CHEN, PENG-SHENG · 2005 to 2010
$2.3M
NERVE SPROUTING AND ELECTRICAL REMODELINGR01HL066389 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHEN, PENG-SHENG · 2000 to 2003
$1.5M
IMAGING ASSISTED INTERACTIVE VENTRICULAR DEFIBRILLATIONR01HL058533 · NHLBI · VANDERBILT UNIVERSITY · PI LIN, SHIEN-FONG · 1999 to 2006
$1.1M
NHLBI NIH HHS P01 HL078931NHLBI NIH HHS P01 HL78931NHLBI NIH HHS R01 HL078932NHLBI NIH HHS R01 HL58533NHLBI NIH HHS R01 HL66389NHLBI NIH HHS R01 HL71140NHLBI NIH HHS R01 HL78932
6 · The paper itself

Abstract

backgroundBeta3-adrenergic receptor (beta3-AR) stimulation inhibits cardiac contractility.

objectiveThis study sought to test the hypothesis that beta3-AR stimulation is antiarrhythmic.

methodsWe implanted a radio transmitter for continuous electrocardiogram monitoring in 18 dogs with a tendency for high incidence of spontaneous ventricular tachycardia (VT). Ten of 18 had subcutaneous continuous BRL37344 (beta3-AR agonist) infusion (experimental group) for 1 month. The other dogs were controls. Western blotting studies were performed on tissues sampled from the noninfarcted left ventricular free wall of all dogs that survived the 60-day follow-up period.

resultsPhase 2 VT appeared significantly later in the experimental group than in the control group (P <.05). The number of VT episodes in the experimental group was significantly lower than in the control group during both the first month (0.5 +/- 0.95 episodes/day vs. 2.6 +/- 2.3 episodes/day) and the second month (0.2 +/- 0.2 episode/day vs. 1.2 +/- 1.1 episodes/day, P <.05 for both). The experimental group had shorter QTc than control (P <.002). The experimental group had decreased protein levels for sodium calcium exchanger and dihydropyridine receptor, increased beta3-AR expression, without changes in beta1-AR, beta2-AR. The average heart weight and the left ventricular free wall thickness in the experimental group (226 +/- 17 g and 15.1 +/- 1.2 mm, respectively) was significantly lower than in the control group (265 +/- 21 g and 17.4 +/- 2.5 mm, respectively, P <.05 for both). There was no difference in the incidences of sudden cardiac death in these 2 groups of dogs.

conclusionBeta3-AR stimulation significantly reduces the occurrence of ventricular tachycardia.

Indexed as

Adrenergic beta-3 Receptor AgonistsAdrenergic beta-AgonistsAnimalsAnti-Arrhythmia AgentsBlotting, WesternDeath, Sudden, CardiacDogsElectrocardiographyEthanolaminesHeart BlockImmunohistochemistryMyocardial ContractionMyocardial InfarctionPotassium ChannelsRisk FactorsTachycardia, VentricularAdrenergic beta-3 Receptor AgonistsAdrenergic beta-AgonistsAnti-Arrhythmia AgentsBRL 37344EthanolaminesPotassium Channels

Identifiers

PMID18242556
PMCPMC2722709
OpenAlexW2088008522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.