ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Age-related decrease in cardiopulmonary adrenergic neuronal function in children as assessed by I-123 metaiodobenzylguanidine imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology.European journal of nuclear medicine and molecular imaging · 2010Guideline
- What does diagnostic threshold mean? Deterministic and probabilistic considerations.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- The Impact of Ageing on 11C-Hydroxyephedrine Uptake in the Rat Heart.Scientific reports · 2018Article
- I-123 metaiodobenzylguanidine innervation imaging as a tool for norepinephrine transporter research: A possible application for genetic analysis in heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- IsAnnals of nuclear medicine · 2018Article
- Impact of aging on cardiac sympathetic innervation measured byEuropean journal of nuclear medicine and molecular imaging · 2016Article
- Impact of age on myocardial uptake of ¹²³I-mIBG in older adult subjects without coronary heart disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2013Article
- Interobserver variability of heart-to-mediastinum ratio in I-123 MIBG sympathetic imaging.Current cardiology reports · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadioiodinated metaiodobenzylguanidine (MIBG) imaging has been used to evaluate adrenergic nerve activity in different organs. Cardiac and pulmonary MIBG uptake is important in predicting the prognosis of certain cardiopulmonary diseases. It has been reported that cardiac MIBG uptake decreases with age and is significantly lower in the elderly. However, there has been no systemic study on age-related changes in cardiac and pulmonary MIBG uptake in children. This study was undertaken to determine the changes in MIBG uptake in the developing heart and lung in children and adolescents. METHODS AND
resultsMIBG scans of 44 children (16 female and 28 male; age range, 2 months to 19 years) without abnormal uptake were selected from a large pool of patients with whole-body MIBG imaging performed for evaluation of neuroblastoma. All of the selected subjects had a normal physiologic distribution of MIBG and no history of heart or lung diseases. The patients were divided into 4 groups by age: group 1, 0 to 24 months; group 2, 25 to 48 months; group 3, 49 to 72 months; and group 4, 73 months or greater. Cardiac and pulmonary MIBG uptake values (expressed as heart-to-mediastinum [H/M] ratio and lung-to-mediastinum [L/M] ratio, respectively) were determined and compared among the 4 groups. H/M and L/M ratios were noted to decrease with age. The mean H/M and L/M ratios were in group 1, 4.13 +/- 0.66 and 1.53 +/- 0.18, respectively; in group 2, 3.46 +/- 0.71 and 1.26 +/- 0.18, respectively; in group 3, 3.19 +/- 0.94 and 1.13 +/- 0.17, respectively; and in group 4, 2.84 +/- 0.48 and 1.14 +/- 0.14, respectively. There was a significant inverse correlation between H/M ratio and age (r = 0.711, P < .001) as well as between L/M ratio and age (r = 0.718, P < .001).
conclusionCardiac and pulmonary MIBG uptake is inversely related to age in children.
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