ArticleBiochemical and biophysical research communications2008
G protein betagamma dimer expression in cardiomyocytes: developmental acquisition of Gbeta3.
Article in Biochemical and biophysical research communications, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- G protein stoichiometry dictates biased agonism through distinct receptor-G protein partitioning.Scientific reports · 2017Article
- Modulation of Ca²+ activity in cardiomyocytes through caveolae-Gαq interactions.Biophysical journal · 2011Article
- The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through G(βγ)-mediated L-type calcium current disinhibition.Circulation research · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Heterotrimeric G proteins are comprised of a guanine nucleotide binding Galpha subunit and the Gbetagamma dimers that link G protein-coupled receptors (GPCRs) to effectors. This study focuses on the expression and localization patterns for certain Gbeta and Ggamma subunits in neonatal and adult cardiomyocytes. We identify developmental downregulation of Gbeta1, Gbeta2, and Ggamma2, and a switch in the molecular form of Ggamma3, in cardiomyocytes. Gbeta1 is highly localized to caveolae membranes, whereas Gbeta2 is identified in caveolae and other membrane fractions. Gbeta3 is not detected in neonatal cardiomyocytes, but rather Gbeta3 is upregulated in adult cardiomyocytes and detected in the caveolae and soluble fractions. The observation that cardiomyocytes co-express multiple Gbeta and Ggamma subunits in a developmentally regulated manner, and that these Gbeta and Ggamma subunits assume distinct subcellular localization patterns, provides for a high level of signaling specificity in the heart.
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Registered trials
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