ArticleBrain, behavior, and immunity2008
Effects of an exercise challenge on mobilization and surface marker expression of monocyte subsets in individuals with normal vs. elevated blood pressure.
Article in Brain, behavior, and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Effects of Probiotic Supplementation on Immune and Inflammatory Markers in Athletes: A Meta-Analysis of Randomized Clinical Trials.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Probiotic supplementation in marathonists and its impact on lymphocyte population and function after a marathon: a randomized placebo-controlled double-blind study.Scientific reports · 2020Trial
- Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans.The Journal of clinical endocrinology and metabolism · 2019Trial
- Exercise reduced pentraxin 3 levels produced by endotoxin-stimulated human peripheral blood mononuclear cells in obese individuals.Experimental biology and medicine (Maywood, N.J.) · 2017Trial
- Change of walking distance in intermittent claudication: impact on inflammation, oxidative stress and mononuclear cells: a pilot study.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Chemokine Receptor Profile of Circulating Leukocyte Subsets in Response to Acute High-Intensity Interval Training.Biomolecules · 2026Article
- Perceived discrimination and monocyte abundance in older adults: Findings from the Health and Retirement Study.Psychoneuroendocrinology · 2025Article
- Comparison of thermoregulatory, cardiovascular, and immune responses to different passive heat therapy modalities.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy.International journal of biological sciences · 2025Review
- Harnessing the immunomodulatory effects of exercise to enhance the efficacy of monoclonal antibody therapies against B-cell haematological cancers: a narrative review.Frontiers in oncology · 2023Review
- Article
- Exercise Regulates the Immune System.Advances in experimental medicine and biology · 2020Review
- Monocyte Subsets in Atherosclerosis and Modification with Exercise in Humans.Antioxidants (Basel, Switzerland) · 2018Review
- The "Journal of functional morphology and kinesiology · 2018Article
- Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via βBrain, behavior, and immunity · 2017Article
- Beta-adrenergic receptor mediated inflammation control by monocytes is associated with blood pressure and risk factors for cardiovascular disease.Brain, behavior, and immunity · 2015Article
- Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications.Brain, behavior, and immunity · 2015Review
- Acute exercise-induced response of monocyte subtypes in chronic heart and renal failure.Mediators of inflammation · 2014Article
- Cardiopulmonary exercise capacity and preoperative markers of inflammation.Mediators of inflammation · 2014Article
- Influence of physical activity and nutrition on obesity-related immune function.TheScientificWorldJournal · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
High blood pressure (BP) and monocyte activation are associated with atherogenic processes. Especially, CD16 expressing monocytes are shown to be activated in many inflammatory conditions but their characteristics in hypertension is unknown. We compared CD16(++), CD16(+) and CD16(-) monocyte populations and their cellular adhesion molecule (CAM), chemokine receptor, and activation marker expression in response to a moderate 20-min treadmill exercise bout at 65-70% V O(2peak) in 44 participants with elevated (EBP) or normal BP (NBP). Blood was drawn before, immediately after, and 10min after exercise. Phenotyping of monocytes and detection of surface markers were done by flow cytometry. Monocyte subset by exercise [pre, post, 10-min post] repeated measures ANOVA and group [EBP vs. NBP] by exercise repeated measures of ANCOVA with age, BMI, and fitness as covariates were employed. Circulating numbers of all the three monocyte subsets increased after exercise (p<0.001), with the largest % increase for CD16(+)CD14(++). Percents of CD16(++)CD14(+) and CD16(+)CD14(++) increased, whereas % CD16(-)CD14(++) decreased (p<0.001). Also, pre to post exercise changes in CD62L, CD11b, CXCR2, and HLA-DR expression were different among the monocyte subsets (p's<0.001). BP status did not significantly affect monocyte subset trafficking, although post-exercise changes in CD62L and CXCR2 levels were greater in EBP individuals (p<0.05). We conclude that exercise leads to a different mobilization among monocyte subsets based on CD16 expression. Individuals with high BP showed greater responses to a physical challenge in some monocyte chemokine receptors and selectins, but its clinical implications need further examination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.