ArticleDevelopmental biology2008
Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates.
Article in Developmental biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species.BMC biology · 2025Article
- The power of the (imperfect) palindrome: Sequence-specific roles of palindromic motifs in gene regulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Review
- A combinatorial cis-regulatory logic restricts color-sensing Rhodopsins to specific photoreceptor subsets in Drosophila.PLoS genetics · 2021Article
- Comparative transcriptome analyses of the Drosophila pupal eye.G3 (Bethesda, Md.) · 2021Article
- Two temporal functions of Glass: Ommatidium patterning and photoreceptor differentiation.Developmental biology · 2016Article
- Ancient default activators of terminal photoreceptor differentiation in the pancrustacean compound eye: the homeodomain transcription factors Otd and Pph13.Current opinion in insect science · 2016Review
- Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Common transcriptional mechanisms for visual photoreceptor cell differentiation among Pancrustaceans.PLoS genetics · 2014Article
- Conserved roles of ems/Emx and otd/Otx genes in olfactory and visual system development in Drosophila and mouse.Open biology · 2013Review
- Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- The retinal mosaics of opsin expression in invertebrates and vertebrates.Developmental neurobiology · 2011Review
- Transphyletic conservation of developmental regulatory state in animal evolution.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- dlx and sp6-9 Control optic cup regeneration in a prototypic eye.PLoS genetics · 2011Article
- Review
- Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events.Developmental biology · 2010Article
- Pph13 and orthodenticle define a dual regulatory pathway for photoreceptor cell morphogenesis and function.Development (Cambridge, England) · 2010Article
- A cis-regulatory signature for chordate anterior neuroectodermal genes.PLoS genetics · 2010Article
- Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epithelia.Current topics in developmental biology · 2010Review
- Eye evolution: common use and independent recruitment of genetic components.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
Homeobox transcription factors of the vertebrate CRX/OTX family play critical roles in photoreceptor neurons, the rostral brain and circadian processes. In mouse, the three related proteins, CRX, OTX1, and OTX2, fulfill these functions. In Drosophila, the single founding member of this gene family, called orthodenticle (otd), is required during embryonic brain and photoreceptor neuron development. We have used global gene expression analysis in late pupal heads to better characterize the post-embryonic functions of Otd in Drosophila. We have identified 61 genes that are differentially expressed between wild type and a viable eye-specific otd mutant allele. Among them, about one-third represent potentially direct targets of Otd based on their association with evolutionarily conserved Otd-binding sequences. The spectrum of biological functions associated with these gene targets establishes Otd as a critical regulator of photoreceptor morphology and phototransduction, as well as suggests its involvement in circadian processes. Together with the well-documented role of otd in embryonic patterning, this evidence shows that vertebrate and fly genes contribute to analogous biological processes, notwithstanding the significant divergence of the underlying genetic pathways. Our findings underscore the common evolutionary history of photoperception-based functions in vertebrates and invertebrates and support the view that a complex nervous system was already present in the last common ancestor of all bilateria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.