ArticleBrain research2008
Localization in stereocilia, plasma membrane, and mitochondria suggests diverse roles for NMHC-IIa within cochlear hair cells.
Article in Brain research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- The Clinical Details ofGenes · 2026Article
- Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss.Cancer research communications · 2025Article
- Article
- Review
- Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14.Cancer research · 2019Article
- Positively charged residues within the MYO19 MyMOMA domain are essential for proper localization of MYO19 to the mitochondrial outer membrane.Cytoskeleton (Hoboken, N.J.) · 2016Article
- Cochlear implantation is safe and effective in patients with MYH9-related disease.Orphanet journal of rare diseases · 2014Article
- [Hereditary sensorineural hearing impairment and macrothrombocytopenia: a rare MYH9 gene mutation].HNO · 2013Article
- Identification of cisplatin-binding proteins using agarose conjugates of platinum compounds.PloS one · 2013Article
- Proteomic analysis of the organ of corti using nanoscale liquid chromatography coupled with tandem mass spectrometry.International journal of molecular sciences · 2012Article
- Actin and myosin contribute to mammalian mitochondrial DNA maintenance.Nucleic acids research · 2011Article
- Function and expression pattern of nonsyndromic deafness genes.Current molecular medicine · 2009Review
- Early-onset liver mtDNA depletion and late-onset proteinuric nephropathy in Mpv17 knockout mice.Human molecular genetics · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
NMHC-IIa, a nonmuscle myosin heavy chain isoform encoded by MYH9, is expressed in sensory hair cells and its dysfunction is associated with syndromic and nonsyndromic hearing loss. In this study, we investigate the ultrastructural distribution of NMHC-IIa within murine hair cells to elucidate its potential role in hair cell function. Using previously characterized anti-mouse NMHC-IIa antibody detected with immunogold labelling, NMHC-IIa was observed in the stereocilia, in the cytosol along the plasma membrane, and within mitochondria. Within stereocilia, presence of NMHC-IIa is observed throughout its length along the actin core, from the center to the periphery and at its base in the cuticular plate, suggesting a potential role in structural support. Within the sensory hair cells, NMHC-IIa was distributed throughout the cytoplasm and along the plasma membrane. A novel finding of this study is the localization of NMHC-IIa within the mitochondria, with the majority of the label along its inner membrane folds. The presence of NMHC-IIa within heterogeneous areas of the hair cell suggests that it may play different functional roles in these distinct regions. Thus, mutant NMHC-IIa may cause hearing loss by affecting hair cell dysfunction through structural and or functional disruption of its stereocilia, plasma membrane, and/or mitochondria.
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Registered trials
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