ReviewCritical care clinics2008
Mechanisms of neuromuscular dysfunction in critical illness.
Review in Critical care clinics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04014439 (Relationship Between Neutrophil to Lymphocyte Ratio and Prealbumin Serum Levels With Diaphragm Thickness in Critical Patients), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relationship Between Neutrophil to Lymphocyte Ratio and Prealbumin Serum Levels With Diaphragm Thickness in Critical Patients
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.
- Pooled it
- Trial
- Connexin hemichannels and early atrophic signaling in muscle during sepsis.Frontiers in physiology · 2025Article
- Clinical and Epidemiological Characteristics of Patients with COVID-19 Admitted to the Intensive Care Unit: A Two-Year Retrospective Analysis.Life (Basel, Switzerland) · 2023Article
- Molecular Mechanisms Underlying Intensive Care Unit-Acquired Weakness and Sarcopenia.International journal of molecular sciences · 2022Review
- Protective Effects of Glutamine and Leucine Supplementation on Sepsis-Induced Skeletal Muscle Injuries.International journal of molecular sciences · 2021Article
- Related factors of the nursing diagnosis ineffective breathing pattern in an intensive care unit.Revista latino-americana de enfermagem · 2019Observational
- Effects of Neuromuscular Electrical Stimulation of the Quadriceps and Diaphragm in Critically Ill Patients: A Pilot Study.Critical care research and practice · 2018Article
- Using M-mode ultrasonography to assess diaphragm dysfunction and predict the success of mechanical ventilation weaning in elderly patients.Journal of thoracic disease · 2017Article
- Review of Critical Illness Myopathy and Neuropathy.The Neurohospitalist · 2017Article
- Reduced motor neuron excitability is an important contributor to weakness in a rat model of sepsis.Experimental neurology · 2016Article
- [Critical illness polyneuropathy and myopathy as neurological complications of sepsis].Der Nervenarzt · 2016Review
- Physical activity, muscle strength, and exercise capacity 3 months after severe sepsis and septic shock.Intensive care medicine · 2015Article
- Critical Illness Neuromyopathy Complicating Akinetic Crisis in Parkinsonism: Report of 3 Cases.Medicine · 2015Article
- The impact of extended bed rest on the musculoskeletal system in the critical care environment.Extreme physiology & medicine · 2015Review
- Acute and long-term dysphagia in critically ill patients with severe sepsis: results of a prospective controlled observational study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Observational
- Reduced motoneuron excitability in a rat model of sepsis.Journal of neurophysiology · 2013Article
- Anesthesia with propofol induces insulin resistance systemically in skeletal and cardiac muscles and liver of rats.Biochemical and biophysical research communications · 2013Article
- A 17 year-old girl with a demyelinating disease requiring mechanical ventilation: a case report.BMC research notes · 2013Article
- Long-term neuromuscular sequelae of critical illness.Journal of neurology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The development of neuromuscular dysfunction (NMD) during critical illness is increasingly recognized as a cause of failure to wean from mechanical ventilation and is associated with significant morbidity and mortality. At times, it is difficult to identify the presence of NMD and distinguish the etiology of the weakness in patients with critical illness, but subtle clinical findings and bedside electrophysiologic testing are helpful in establishing the diagnosis. This article describes the clinical spectrum of acquired neuromuscular weakness in the setting of critical illness, provides an approach to diagnosis, and discusses its pathogenesis. Finally, a defective sodium channel regulation as a unifying mechanism underlying NMD in critically ill patients is proposed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.