ReviewCurrent atherosclerosis reports2007
Lipid peroxidation and redox-sensitive signaling pathways.
Review in Current atherosclerosis reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Environmental metals, prostaglandin pathways, and immune-mediated neuroinflammation in autism spectrum disorder: A secondary analysis of peripheral biomarker studies.Metabolic brain disease · 2026Article
- Participation of lipids in the tumor response to photodynamic therapy and its exploitation for therapeutic gain.Journal of lipid research · 2025Review
- Impact ofCells · 2024Article
- X-ray Activated Nanoplatforms for Deep Tissue Photodynamic Therapy.Nanomaterials (Basel, Switzerland) · 2023Review
- Redox Regulation and Oxidative Stress: The Particular Case of the Stallion Spermatozoa.Antioxidants (Basel, Switzerland) · 2019Review
- Cross-talk between lipid and protein carbonylation in a dynamic cardiomyocyte model of mild nitroxidative stress.Redox biology · 2017Article
- Infusion of Hibiscus sabdariffa L. Modulates Oxidative Stress in Patients with Marfan Syndrome.Mediators of inflammation · 2016Article
- Photodynamic therapy: current status and future directions.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Review
- Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Regulation of NF-κB-induced inflammatory signaling by lipid peroxidation-derived aldehydes.Oxidative medicine and cellular longevity · 2013Review
- Mitochondria as a source and target of lipid peroxidation products in healthy and diseased heart.Clinical and experimental pharmacology & physiology · 2012Review
- Nutraceuticals as Ligands of PPARγ.PPAR research · 2012Article
- ALDOSE REDUCTASE: New Insights for an Old Enzyme.Biomolecular concepts · 2011Article
- Atherogenic ω-6 Lipids Modulate PPAR- EGR-1 Crosstalk in Vascular Cells.PPAR research · 2011Article
- Regulation of pentraxin-3 by antioxidants.British journal of anaesthesia · 2009Article
- Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegeneration.Mutation research · 2009Review
- Role of oxidative stress in adaptive responses in special reference to atherogenesis.Journal of clinical biochemistry and nutrition · 2008Article
- Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo.Chemical research in toxicology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of evidence suggests that many of the effects of vascular dysfunction on cardiovascular diseases are mediated by the products of nonenzymatic reactions, such as the peroxidative degradation of polyunsaturated fatty acids (ie, lipid peroxidation). These degradation products are electrophilic reactive compounds and are thought to have a major impact on human health and lifespan by acting on proteins and genes. The oxidized lipids bound to the biomacromolecules can be detected as constituents in human patients with increased risk factors or clinical manifestations of lifestyle-related diseases, such as atherosclerosis. However, it appears that there are several sensor mechanisms in which specific cellular proteins directly interact with these electrophilic molecules. Moreover, a number of lipid peroxidation products have been shown as inducers for activation of the redox-related cell signaling mechanism, which integrate with other signaling pathways to control cellular responses to extracellular stimuli.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.