ReviewCurrent atherosclerosis reports2007
Genetic determinants of C-reactive protein.
Review in Current atherosclerosis reports, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Effects of different doses of physical activity on C-reactive protein among women.Medicine and science in sports and exercise · 2010Trial
- Associations of circulating c-reactive protein levels with central Alzheimer's disease biomarkers.The journal of prevention of Alzheimer's disease · 2026Observational
- Investigation of the Frequency of CRP Gene Polymorphism in Rheumatoid Arthritis and Associations with CRP Level and Clinical Involvements of the Disease.Balkan journal of medical genetics : BJMG · 2025Article
- Association between parental high-sensitive C-reactive protein and hypertension in offspring: an intergenerational study.Clinical hypertension · 2025Article
- Analysis of the Effects ofGenes · 2023Article
- Mutations on a conserved distal enhancer in the porcine C-reactive protein gene impair its expression in liver.Frontiers in immunology · 2023Article
- Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets.PeerJ · 2021Article
- Obese-Inflammatory Phenotypes in Heart Failure With Preserved Ejection Fraction.Circulation. Heart failure · 2020Article
- C-reactive protein +1444CT (rs1130864) genetic polymorphism is associated with the susceptibility to systemic lupus erythematosus and C-reactive protein levels.Clinical rheumatology · 2017Article
- Serum levels of high sensitive C reactive protein in healthy adults from southern Brazil.Journal of clinical laboratory analysis · 2013Article
- Association of tumor necrosis factor β genetic polymorphism and sepsis susceptibility.Experimental and therapeutic medicine · 2011Article
- C-reactive protein and risk of lung cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2010Article
- APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample.Human immunology · 2010Article
- C-reactive protein as a predictor of disease in smokers and former smokers: a review.International journal of clinical practice · 2009Review
- Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men.Atherosclerosis · 2009Article
- The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk.Current atherosclerosis reports · 2009Review
- The interaction of adiposity with the CRP gene affects CRP levels: age, gene/environment susceptibilty-Reykjavik study.International journal of obesity (2005) · 2009Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
C-reactive protein (CRP) levels are a complex phenotype with both genetic and environmental determinants. Recent work has highlighted the impact of genetic variants within the CRP gene as well as other candidate genes, often chosen for their role in the inflammatory pathway, on CRP levels. Emerging work shows the association of such genetic variants in CRP not only to CRP levels, but also to variation of CRP levels in the acute phase response. Work on the relation of genetic variants within CRP to cardiovascular disease has had varied results. Whole-genome association studies to investigate the genetic determinants of CRP levels in an unbiased manner are ongoing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.