ArticleClinical and experimental immunology2008
Decreased serum lipocalin-2 levels in human immunodeficiency virus-infected patients: increase during highly active anti-retroviral therapy.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- SARS-CoV-2 infection induces expression and secretion of lipocalin-2 and regulates iron in a human lung cancer xenograft model.BMB reports · 2023Article
- The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL).International journal of molecular sciences · 2023Review
- Serum siderocalin levels in patients with tuberculosis and HIV infection.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019Article
- Adipokines levels in HIV infected patients: lipocalin-2 and fatty acid binding protein-4 as possible markers of HIV and antiretroviral therapy-related adipose tissue inflammation.BMC infectious diseases · 2018Article
- Cystic fluid neutrophil gelatinase-associated lipocalin (NGAL) concentration in differential diagnosis of pancreatic cystic lesions: a new factor enters the scene?Przeglad gastroenterologiczny · 2018Article
- Siderophore-based immunization strategy to inhibit growth of enteric pathogens.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques.The Journal of clinical investigation · 2015Article
- Neutrophil gelatinase-associated lipocalin and innate immune responses to bacterial infections.Medical microbiology and immunology · 2015Review
- Urinary biomarkers of kidney diseases in HIV-infected children.Proteomics. Clinical applications · 2015Review
- Renal transplantation in human immunodeficiency virus (HIV)-positive children.Pediatric nephrology (Berlin, Germany) · 2015Review
- Plasma Neutrophil Gelatinase-Associated Lipocalin Is Primarily Related to Inflammation during Sepsis: A Translational Approach.PloS one · 2015Article
- Article
- A novel biomarker in the diagnosis of parapneumonic effusion: neutrophil gelatinase-associated lipocalin.Multidisciplinary respiratory medicine · 2014Article
- Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2.Clinical and experimental immunology · 2013Article
- Prognostic value of serum neutrophil gelatinase-associated lipocalin in metastatic and nonmetastatic colorectal cancer.World journal of surgery · 2013Article
- Siderocalins: Siderophore binding proteins evolved for primary pathogen host defense.Current opinion in chemical biology · 2013Review
- The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer.Biochimica et biophysica acta · 2012Review
- Iron metabolism and the innate immune response to infection.Microbes and infection · 2012Review
- Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2.Infection and immunity · 2011Article
- The role of iron in the immune response to bacterial infection.Immunologic research · 2011Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although neutrophil gelatinase-associated lipocalin (NGAL) may play a pivotal role in the innate immune response, there are currently no data on NGAL levels in human immunodeficiency virus (HIV)-infected patients. In this study we aimed to examine the regulation of NGAL in HIV infection. The regulation of NGAL in HIV infection was examined by different experimental approaches, including studies in peripheral blood and mononuclear cells (MNC) from bone marrow aspirates before and during highly active anti-retroviral therapy (HAART). We found that: before initiating HAART, HIV-infected patients (n = 37) had significantly decreased serum NGAL levels compared with healthy controls (n = 26); (ii) during HAART, there was a gradual and significant increase in NGAL concentrations reaching levels comparable to those in healthy controls after 12 months; (iii) this increase was seen primarily in virological responders to HAART (HIV RNA level <200 copies/ml after 24 months); (iv) phytohaemagglutinin-stimulated NGAL release in MNC cells from bone marrow aspirates was decreased in untreated HIV-infected patients compared with healthy controls, but increased after 26 weeks on HAART; and (v) there was a significant positive correlation between neutrophil counts and NGAL levels at all time-points during HAART. We have shown decreased NGAL levels in HIV-infected patients, potentially reflecting decreased number and function of neutrophils as well as impaired bone marrow myelopoiesis. These abnormalities were reversed by successful HAART. Our findings underscore further the involvement of neutrophils and innate immunity in HIV-related immunodeficiency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.