ArticleClinical and experimental immunology2008
Possible association between thyroid autoimmunity and Menière's disease.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Inner Ear Dysfunction in Thyroid Disease: A Scoping Review.Medicina (Kaunas, Lithuania) · 2025Article
- Endocrine polyautoimmunity: Mechanistic insights and the future of AI-driven diagnostics.EXCLI journal · 2025Review
- Diverse phenotype of Ménière's disease associated with family history, thyroid disorder, migraine and associated disorders.Journal of otology · 2024Article
- Vestibular Dysfunction in Euthyroid Children with Hashimoto's Thyroiditis.The journal of international advanced otology · 2024Article
- Statistical Associations between Vestibular Pathologies and Hypothyroidism: A Retrospective Study.Journal of clinical medicine · 2024Article
- Thyroid Axis and Vestibular Physiopathology: From Animal Model to Pathology.International journal of molecular sciences · 2023Review
- Elevated G-CSF, IL8, and HGF in patients with definite Meniere's disease may indicate the role of NET formation in triggering autoimmunity and autoinflammation.Scientific reports · 2022Article
- Prevalence of Ménière's Disease in Syrian Patients with hypothyroidism: Cross-sectional study.Annals of medicine and surgery (2012) · 2022Article
- Evaluation of a large cohort of adult patients with Ménière's disease: bedside and clinical history.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2020Article
- Association between Ménière's disease and thyroid diseases: a nested case-control study.Scientific reports · 2020Article
- Climacteric symptoms are related to thyroid status in euthyroid menopausal women.Journal of endocrinological investigation · 2020Article
- Hypothyroidism is an independent risk factor for Menière's disease: A population-based cohort study.Medicine · 2019Article
- Circulating Immune Complexes and Heat Shock Protein 70 in the Sera of Patients with Sudden Sensorineural Hearing Loss.The journal of international advanced otology · 2018Article
- Autoimmune vertigo: an update on vestibular disorders associated with autoimmune mechanisms.Immunologic research · 2018Review
- RNA-sequencing study of peripheral blood mononuclear cells in sporadic Ménière's disease patients: possible contribution of immunologic dysfunction to the development of this disorder.Clinical and experimental immunology · 2018Article
- Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment.Journal of immunology research · 2018Review
- The aetiopathologies of Ménière's disease: a contemporary review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2017Review
- Clinical Subgroups in Bilateral Meniere Disease.Frontiers in neurology · 2016Article
- Article
- The role of thyroid and parathyroid metabolism disorders in the etiology of sudden onset dizziness.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various aetiopathological mechanisms have been postulated to be at the root of Menière's disease (MD), and some data suggest that there may be also an underlying autoimmune factor. In fact, Menière patients manifest certain characteristics that are typical of autoimmune involvement association of particular human leucocyte antigen haplotypes, the presence of antibodies against internal ear antigens. In this study, we evaluated the association between thyroid autoimmunity and MD in a non-selected group of patients. We recruited 50 consecutive MD patients and two groups as controls: group A, 82 healthy volunteers; and group B, 50 subjects suffering from acute unilateral peripheral vestibulopathy. All subjects were submitted to instrumental assessment of cochlear-vestibular function and analysis of thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-TSH receptor antibody (TR-Ab), anti-thyroperoxidase antibody (TPO-Ab) and anti-thyroglobulin antibody (Tg-Ab) in the blood. The prevalence of autoimmune thyroiditis in group B [6/50 (12%); 66.7% TPO-Ab and 33.3% Tg-Ab] was superimposable with the healthy controls [6/82 (7%); 66.7% TPO-Ab and 33.3% Tg-Ab]. In contrast, 38% of the MD patients (P = 0.0001 versus group A and group B) had significant autoantibody levels (68.4% TPO-Ab; 15.8% TPO-Ab + TR-Ab; 10.5% Tg-Ab; 5.2% TPO-Ab + Tg-Ab). Furthermore, 14% of the MD patients were hyperthyroid under l-thyroxine therapy, while no dysfunction was seen in the control groups. Overall, our data demonstrate a significant association between MD and thyroid autoimmunity, which suggests that an autoimmune factor is involved in the aetiopathogenesis of this disease. These findings suggest that it should be useful to submit MD patients to multi-disciplinary clinical investigation.
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