Evidence map›Paper›PMID 18240345›Full record

ArticleWorld journal of gastroenterology2008

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas: correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression.

Valeska Portela Lima, Marcos Antonio Pereira de Lima, Angela Rosa André, Márcia Valéria Pitombeira Ferreira, Marcos Aurélio Pessoa Barros, Sílvia Helena Barem Rabenhorst

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Article in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. International journal of molecular sciences · 2023
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  7. Article
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  10. Metabolic Control by DNA Tumor Virus-Encoded Proteins.Pathogens (Basel, Switzerland) · 2021
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  20. Differential expression of MYC in H. pylori-related intestinal and diffuse gastric tumors.Virchows Archiv : an international journal of pathology · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Valeska Portela LimaDepartment of Pathology and Forensic Medicine, Federal University of Ceará State, Porangabussu campus, Fortaleza, Ceará State, 60183-630, Brazil. valeskacb@yahoo.com.br
Marcos Antonio Pereira de Lima
Angela Rosa André
Márcia Valéria Pitombeira Ferreira
Marcos Aurélio Pessoa Barros
Sílvia Helena Barem Rabenhorst
Universidade Federal do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression.

methodsseventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation.

resultsThe positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P = 0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups.

conclusionThe frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents.

Indexed as

Genes, p53Stomach NeoplasmsAdolescentAdultAgedAntigens, BacterialBacterial Proteinsbcl-2-Associated X ProteinBiomarkers, TumorChildChild, PreschoolEpstein-Barr Virus InfectionsFemaleHelicobacter InfectionsHelicobacter pyloriHerpesvirus 4, HumanAntigens, BacterialBacterial Proteinsbcl-2-Associated X ProteinBiomarkers, TumorcagA protein, Helicobacter pyloriProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-mycTumor Suppressor Protein p53

Identifiers

PMID18240345
PMCPMC2687055
OpenAlexW2060704131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.