ReviewWorld journal of gastroenterology2008
Stem cells for liver tissue repair: current knowledge and perspectives.
Review in World journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 69 citations in OpenAlex.
- [Induction of peripheral blood mononuclear cells to hepatocyte-like cells and preliminary study of cell response to injury under the effect of acetaminophen].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- The hematopoietic system in the context of regenerative medicine.Methods (San Diego, Calif.) · 2016Review
- Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis.EXCLI journal · 2016Article
- Encapsulated Whole Bone Marrow Cells Improve Survival in Wistar Rats after 90% Partial Hepatectomy.Stem cells international · 2016Article
- Early activated hepatic stellate cell-derived molecules reverse acute hepatic injury.World journal of gastroenterology · 2015Article
- Cell differentiation mediated by co-culture of human umbilical cord blood stem cells with murine hepatic cells.In vitro cellular & developmental biology. Animal · 2015Article
- Novel management of acute or secondary biliary liver conditions using hepatically differentiated human dental pulp cells.Tissue engineering. Part A · 2015Article
- Bone mesenchymal stem cell transplantation via four routes for the treatment of acute liver failure in rats.International journal of molecular medicine · 2014Article
- Comparison of the liver function and hepatic specific genes expression in cultured mesenchymal stem cells and hepatocytes.Iranian journal of basic medical sciences · 2014Article
- VEGF(165) expressing bone marrow mesenchymal stem cells differentiate into hepatocytes under HGF and EGF induction in vitro.Cytotechnology · 2012Article
- Therapeutic potential of transplanted placental mesenchymal stem cells in treating Chinese miniature pigs with acute liver failure.BMC medicine · 2012Article
- Administration of bone marrow derived mesenchymal stem cells into the liver: potential to rescue pseudoxanthoma elasticum in a mouse model (Abcc6-/-).Journal of biomedicine & biotechnology · 2012Article
- SAMe and HuR in liver physiology: usefulness of stem cells in hepatic differentiation research.Methods in molecular biology (Clifton, N.J.) · 2012Review
- Bivalirudin in combination with heparin to control mesenchymal cell procoagulant activity.PloS one · 2012Article
- A review on the therapeutic potential of embryonic and induced pluripotent stem cells in hepatic repair.Journal of natural science, biology, and medicine · 2011Article
- Efficacy of mesenchymal stem cells in suppression of hepatocarcinorigenesis in rats: possible role of Wnt signaling.Journal of experimental & clinical cancer research : CR · 2011Article
- Stem cell-based therapies for liver diseases: state of the art and new perspectives.Stem cells international · 2010Article
- Bone marrow stem cells and liver regeneration.Experimental hematology · 2010Review
- Mesenchymal progenitor cells derived from traumatized human muscle.Journal of tissue engineering and regenerative medicine · 2009Article
- Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives.World journal of gastroenterology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cells from extra- or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.