ArticleHistochemistry and cell biology2008
Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development.
Article in Histochemistry and cell biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- NEDD1 Promotes the Development of Lung Adenocarcinoma and Can be Used as a Prognostic Marker.Journal of Cancer · 2024Article
- Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes.The Journal of cell biology · 2017Article
- The molecular mechanisms underlying lens fiber elongation.Experimental eye research · 2017Review
- Ulk4 Is Essential for Ciliogenesis and CSF Flow.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Loss of γ-tubulin, GCP-WD/NEDD1 and CDK5RAP2 from the Centrosome of Neurons in Developing Mouse Cerebral and Cerebellar Cortex.Acta histochemica et cytochemica · 2015Article
- Loss of CDK5RAP2 affects neural but not non-neural mESC differentiation into cardiomyocytes.Cell cycle (Georgetown, Tex.) · 2015Article
- A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts.Cell death & disease · 2010Article
- A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.PloS one · 2010Article
- Extending the knowledge in histochemistry and cell biology.Histochemistry and cell biology · 2010Review
- State-of-the-art technologies, current opinions and developments, and novel findings: news from the field of histochemistry and cell biology.Histochemistry and cell biology · 2008Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the primary microtubule-organizing centre of the mammalian cell, the centrosome plays many important roles during cell growth and organization. This is evident across a broad range of cell types and processes, such as the proliferation, differentiation and polarity of neural cells. Additionally, given its localization and function, there are likely to be many more processes that rely on the centrosome that have not yet been characterized. Currently, little is known about centrosomal dynamics during mammalian development. In this study, we have analyzed Nedd1 protein expression to characterize the localization of the centrosome during some aspects of mouse embryogenesis. Using a Nedd1 antibody we have demonstrated the colocalization of Nedd1 with centrosomal markers. We found strong expression of Nedd1, and therefore the centrosome, in highly proliferating cells during neural development. Additionally, Nedd1 was found to have high expression in the cytoplasm of a subset of cells in the dorsal root ganglia. We have also shown a distinct, polarized centrosomal localization of Nedd1 in the developing lens, retina and other polarized tissues. This study reveals the localization of Nedd1 and the centrosome during important processes in mouse embryogenesis and provides a basis for further study into its role in development.
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