ArticleObesity (Silver Spring, Md.)2008
Association of the FTO gene with BMI.
Article in Obesity (Silver Spring, Md.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 4 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis.Diabetologia · 2012Pooled it
- The epithelial sodium channel γ-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses.Hypertension (Dallas, Tex. : 1979) · 2011Pooled it
- Pooled it
- Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes.BMC medical genetics · 2009Pooled it
- Trial
- A randomized trial of the clinical utility of genetic testing for obesity: design and implementation considerations.Clinical trials (London, England) · 2014Trial
- A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity.Obesity (Silver Spring, Md.) · 2010Trial
- Redesigning medicine: integrating sex and gender for better health outcomes.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa.Scientific reports · 2024Article
- Investigation of genetic markers associated to type 2 diabetes mellitus in Santarém-Pará.Genetics and molecular biology · 2024Article
- Lack of association of the alpha-ketoglutarate-dependent dioxygenase (FTO) gene polymorphisms with pulmonary tuberculosis risk: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2023Review
- "GENYAL" Study to Childhood Obesity Prevention: Methodology and Preliminary Results.Frontiers in nutrition · 2022Article
- Ramadan Diurnal Intermittent Fasting Is Associated With Attenuated FTO Gene Expression in Subjects With Overweight and Obesity: A Prospective Cohort Study.Frontiers in nutrition · 2021Article
- No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males.Nutrients · 2020Article
- A Comprehensive Genome-Wide and Phenome-Wide Examination of BMI and Obesity in a Northern Nevadan Cohort.G3 (Bethesda, Md.) · 2020Article
- The Effect Sizes ofGenes · 2020Article
- The Interaction between Genetic Polymorphisms inJournal of personalized medicine · 2019Article
- Common Polymorphisms Linked to Obesity and Cardiovascular Disease in Europeans and Asians are Associated with Type 2 Diabetes in Mexican Mestizos.Medicina (Kaunas, Lithuania) · 2019Article
- The FTO genetic variants are associated with dietary intake and body mass index amongst Emirati population.PloS one · 2019Article
- A sibling method for identifying vQTLs.PloS one · 2018Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects. To replicate these findings, the previously reported SNP in the FTO gene (rs9939609, T/A) was genotyped in 5,607 subjects from five different Utah studies. The studies included a random sample of the Utah population, families selected for aggregation of extreme thinness, families selected for severe obesity, a series of unrelated severe obesity subjects, and families participating in a 25-year longitudinal study of cardiovascular disease and aging. Results show a strong significant increase in the rs9939609 A allele frequency with increasing BMI (P < 0.0001). In the longitudinal study, FTO genotypes were significantly associated with BMI at a baseline exam, a 2(1/2)-year follow-up exam and a 25-year follow-up exam using an additive genetic model. The mean genotype difference in BMI ranged from 1.3 to 2.1 kg/m(2) across exams. The genotype difference in BMI means was established in youth, and at-risk subjects under age 20 at baseline had a significantly larger 25-year BMI increase (10.0 for A/A; 9.7 for A/T, and 8.5 kg/m(2) for T/T, P = 0.05). We conclude that the BMI increases associated with FTO genotypes begin in youth and are maintained throughout adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.