ReviewCell cycle (Georgetown, Tex.)2008
Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.
Review in Cell cycle (Georgetown, Tex.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- HemaScope: A Tool for Analyzing Single-cell and Spatial Transcriptomics Data of Hematopoietic Cells.Genomics, proteomics & bioinformatics · 2025Article
- Article
- Enhanced expressions of FHL2 and iASPP predict poor prognosis in acute myeloid leukemia.Cancer gene therapy · 2019Article
- A computational model of feedback-mediated hematopoietic stem cell differentiation in vitro.PloS one · 2019Article
- Battling quiescence for tumor eradication: too good to be true?Oncotarget · 2018Article
- Oncogenic N-Ras and Tet2 haploinsufficiency collaborate to dysregulate hematopoietic stem and progenitor cells.Blood advances · 2018Article
- Functional dissection of hematopoietic stem cell populations with a stemness-monitoring system based on NS-GFP transgene expression.Scientific reports · 2017Article
- Understanding Hematopoietic Stem Cell Development through Functional Correlation of Their Proliferative Status with the Intra-aortic Cluster Architecture.Stem cell reports · 2017Article
- Engineering the hematopoietic stem cell niche: Frontiers in biomaterial science.Biotechnology journal · 2015Review
- Jacaric acid inhibits the growth of murine macrophage-like leukemia PU5-1.8 cells by inducing cell cycle arrest and apoptosis.Cancer cell international · 2015Article
- PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.Molecular cell · 2014Article
- Regulation of stem cell function by protein ubiquitylation.EMBO reports · 2014Review
- The Ah receptor in stem cell cycling, regulation, and quiescence.Annals of the New York Academy of Sciences · 2014Review
- Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice.Stem cells and development · 2014Article
- Proteomic analysis of murine bone marrow niche microenvironment identifies thioredoxin as a novel agent for radioprotection and for enhancing donor cell reconstitution.Experimental hematology · 2013Article
- Article
- Regulation of hematopoietic stem cell fate by the ubiquitin proteasome system.Trends in immunology · 2012Review
- Article
- Article
- Negative regulation of cyclin D3 expression by transcription factor c-Ets1 in umbilical cord hematopoietic cells.Acta pharmacologica Sinica · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Chromosomal translocations that disrupt transcriptional regulators are frequently involved in the etiology of leukemia. To gain an understanding of the normal and pathologic roles of these transcriptional regulators, both gain- and loss-of-function mutations have been examined in the context of steady-state hematopoiesis. These studies have identified a remarkable number of genes whose loss-of-function phenotype includes a perturbation of hematopoietic stem cell (HSC) proliferation. As more of these models are generated and analyzed using commonly available tools, the regulatory pathways that control HSC quiescence and proliferation are becoming clearer. An emerging theme is that leukemia-associated transcriptional regulators coordinate the balance of proliferation and quiescence within the HSC pool by modulating the number and frequency of cells transiting the cell cycle. Uncoupling proliferation from differentiation by the aberrant generation of chimeric oncogenes that retain some, but not all of the attributes of the original transcription factor is likely to be an important step during leukemogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.