ArticleThe Journal of physiology2008
Developmental changes in calcium/calmodulin-dependent inactivation of calcium currents at the rat calyx of Held.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Activation of CaExperimental brain research · 2025Article
- Molecular and functional profiling of cell diversity and identity in the lateral superior olive, an auditory brainstem center with ascending and descending projections.Frontiers in cellular neuroscience · 2024Article
- Apparent calcium dependence of vesicle recruitment.The Journal of physiology · 2018Article
- Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Large Ca²⁺-dependent facilitation of Ca(V)2.1 channels revealed by Ca²⁺ photo-uncaging.The Journal of physiology · 2015Article
- Glycinergic inhibition to the medial nucleus of the trapezoid body shows prominent facilitation and can sustain high levels of ongoing activity.Journal of neurophysiology · 2014Article
- Activity-dependent neurotrophin signaling underlies developmental switch of Ca2+ channel subtypes mediating neurotransmitter release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Theoretical models of synaptic short term plasticity.Frontiers in computational neuroscience · 2013Article
- Actin-dependent rapid recruitment of reluctant synaptic vesicles into a fast-releasing vesicle pool.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Similar intracellular Ca2+ requirements for inactivation and facilitation of voltage-gated Ca2+ channels in a glutamatergic mammalian nerve terminal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Egr2::cre mediated conditional ablation of dicer disrupts histogenesis of mammalian central auditory nuclei.PloS one · 2012Article
- Presynaptic Ca2+ influx and vesicle exocytosis at the mouse endbulb of Held: a comparison of two auditory nerve terminals.The Journal of physiology · 2011Article
- Formation and maturation of the calyx of Held.Hearing research · 2011Review
- Endbulb synaptic depression within the range of presynaptic spontaneous firing and its impact on the firing reliability of cochlear nucleus bushy neurons.Hearing research · 2010Article
- Developmental shift to a mechanism of synaptic vesicle endocytosis requiring nanodomain Ca2+.Nature neuroscience · 2010Article
- Interaction between facilitation and depression at a large CNS synapse reveals mechanisms of short-term plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Mechanisms underlying short-term modulation of transmitter release by presynaptic depolarization.The Journal of physiology · 2009Article
- Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca2+ buffering capacity in the developing rat calyx of Held.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2009Article
- Interactions between multiple sources of short-term plasticity during evoked and spontaneous activity at the rat calyx of Held.The Journal of physiology · 2008Article
- Involvement of AMPA receptor desensitization in short-term synaptic depression at the calyx of Held in developing rats.The Journal of physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ca2+-binding to calmodulin (CaM) causes facilitation and/or inactivation of recombinant Ca2+ channels. At the rat calyx of Held, before hearing onset, presynaptic Ca2+ currents (IpCa) undergo Ca2+/CaM-dependent inactivation during repetitive activation at around 1 Hz, implying that this may be a major cause of short-term synaptic depression. However, it remains open whether the Ca2+/CaM-dependent inactivation of IpCa persists in more mature animals. To address this question, we tested the effect of CaM inhibitors on the activity-dependent modulation of IpCa in calyces, before (postnatal day (P) 7-9) and after (P13-15) hearing onset. Our results indicate that the CaM-dependent IpCa inactivation during low-frequency stimulation, and the ensuing synaptic depression, occur only at calyces in the prehearing period. However, CaM immunoreactivity in P8 and P14 calyces was equally strong. Even at P13-15, high frequency stimulation (200-500 Hz) could induce IpCa inactivation, which was attenuated by EGTA (10 mM) or a CaM inhibitor peptide loaded into the terminal. Furthermore, the CaM inhibitor peptide attenuated a transient facilitation of IpCa preceding inactivation observed at 500 Hz stimulation, whereas it had no effect on sustained IpCa facilitations during trains of 50-200 Hz stimulation. These results suggest that the Ca2+/CaM-dependent IpCa modulation requires a high intraterminal Ca2+ concentration, which can be attained at immature calyces during low frequency stimulation, but only during unusually high frequency stimulation at calyceal terminals in the posthearing period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.