ArticleBMC cancer2008
Clinical significance of gelsolin-like actin-capping protein expression in oral carcinogenesis: an immunohistochemical study of premalignant and malignant lesions of the oral cavity.
Article in BMC cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- Macrophage capping protein CapG is a putative oncogene involved in migration and invasiveness in ovarian carcinoma.BioMed research international · 2014Trial
- CapG promoted nasopharyngeal carcinoma cell motility involving Rho motility pathway independent of ROCK.World journal of surgical oncology · 2022Article
- Downregulation of NSD3 (WHSC1L1) inhibits cell proliferation and migration via ERK1/2 deactivation and decreasing CAPG expression in colorectal cancer cells.OncoTargets and therapy · 2019Article
- Candidate Biomarkers and Molecular Mechanism Investigation for Glioblastoma Multiforme Utilizing WGCNA.BioMed research international · 2018Article
- Function of the macrophage-capping protein in colorectal carcinoma.Oncology letters · 2017Article
- DHA-mediated regulation of lung cancer cell migration is not directly associated with Gelsolin or Vimentin expression.Life sciences · 2016Article
- CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment.Journal of the National Cancer Institute · 2016Article
- Proteomic Analysis Revealed the Important Role of Vimentin in Human Cervical Carcinoma HeLa Cells Treated With Gambogic Acid.Molecular & cellular proteomics : MCP · 2016Article
- Gelsolin regulates proliferation, apoptosis, migration and invasion in human oral carcinoma cells.Oncology letters · 2015Article
- Upregulation of transgelin is an independent factor predictive of poor prognosis in patients with advanced pancreatic cancer.Cancer science · 2013Article
- Article
- Periostin, a stroma-associated protein, correlates with tumor invasiveness and progression in nasopharyngeal carcinoma.Clinical & experimental metastasis · 2012Article
- Endocytosis and signaling: cell logistics shape the eukaryotic cell plan.Physiological reviews · 2012Review
- Proteomic analysis of the stroma-related proteins in nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissues.Medical oncology (Northwood, London, England) · 2010Article
- Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency.Molecular biology of the cell · 2009Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGelsolin-like actin-capping protein (CapG) is a ubiquitous gelsolin-family actin-modulating protein involved in cell signalling, receptor-mediated membrane ruffling, phagocytosis, and motility. CapG has generated great interest due to its oncogenic function in the control of cell migration or invasion in a variety of cancer cells. We previously applied proteomic methods to characterize differentially expressed proteins in oral squamous-cell carcinoma (OSCC) cells and detected significantly high expression levels of CapG in OSCC-derived cell lines compared to human normal oral keratinocytes. In the current study, to further determine the potential involvement of CapG in OSCC, we evaluated the status of CapG protein and mRNA expression in human oral premalignant lesions (OPLs) and primary OSCCs and correlated the results with clinicopathologic variables.
methodsMatched normal and tumour tissue sections of 79 human primary OSCCs and 28 OPLs were analyzed for CapG expression by immunohistochemistry (IHC). Correlations between CapG-immunohistochemical staining scores of OSCCs and clinicopathologic features were evaluated by Fisher's exact test. Real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was used to estimate CapG expression at the mRNA level.
resultsIn IHC, substantial up-regulation of CapG protein was observed in primary OSCCs (52%) and OPLs (64%), whereas corresponding normal tissues showed consistently weak or absent immunoreactivity of CapG. qRT-PCR data were consistent with the protein expression status. Moreover, CapG expression was correlated with the TNM stage grading of OSCCs.
conclusionOur finding of frequent dysregulated expression of CapG in premalignant and malignant lesions together with an association with an advanced clinical disease stage suggests that CapG could contribute to cancer development and progression and that CapG may have potential as a biomarker and a therapeutic target for OSCC.
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