ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2007
Rethinking psychosis: the disadvantages of a dichotomous classification now outweigh the advantages.
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies.Schizophrenia bulletin · 2014Pooled it
- Clinical implications of autistic features in the psychosis spectrum: a cross-sectional study using path analysis.BMC psychiatry · 2025Article
- Revealing differential psychotic symptoms in schizophrenia and bipolar I disorder by manifold learning and network analyses.Translational psychiatry · 2025Article
- Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data-Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders.Neuropsychopharmacology reports · 2025Article
- Individualized functional connectome identified generalizable biomarkers for psychiatric symptoms in transdiagnostic patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- A randomized Phase II trial evaluating efficacy, safety, and tolerability of oral BI 409306 in attenuated psychosis syndrome: Design and rationale.Early intervention in psychiatry · 2021Article
- Symptom Profiles in Psychotic Disorder Not Otherwise Specified.Frontiers in psychiatry · 2020Article
- Increased Risk for New-Onset Psychiatric Adverse Events in Patients With Newly Diagnosed Primary Restless Legs Syndrome Who Initiate Treatment With Dopamine Agonists: A Large-Scale Retrospective Claims Matched-Cohort Analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- The classification of eating disorders in China: A categorical model or a dimensional model.The International journal of eating disorders · 2019Article
- Clinical correlates of subsyndromal depression in African American individuals with psychosis: The relationship with positive symptoms and comorbid substance dependence.Schizophrenia research · 2019Article
- Decreased peak alpha frequency and impaired visual evoked potentials in first episode psychosis.NeuroImage. Clinical · 2019Article
- Article
- Aberrant cerebellar connectivity in bipolar disorder with psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- McLean OnTrack: a transdiagnostic program for early intervention in first-episode psychosis.Early intervention in psychiatry · 2017Article
- Schizophrenia.Lancet (London, England) · 2016Review
- Callous traits in children with and without conduct problems predict reduced connectivity when viewing harm to others.Scientific reports · 2016Article
- Sex differences in abnormal white matter development associated with conduct disorder in children.Psychiatry research · 2015Article
- Genome-wide methylome analyses reveal novel epigenetic regulation patterns in schizophrenia and bipolar disorder.BioMed research international · 2015Article
- What is in a name? Renaming schizophrenia as a starting point for moving ahead with its re-conceptualization.Epidemiology and psychiatric sciences · 2013Article
- Clinical and molecular genetics of psychotic depression.Schizophrenia bulletin · 2013Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Emil Kraepelin would clearly recognize his 19th century dichotomy within current operational classifications of psychosis. However, he might be surprised at its survival, given the extent to which it has been undermined by the weight of currently available empirical evidence. The failure of this evidence to influence diagnostic practice reflects not only the comfortable simplicity of the dichotomous approach, but also the fact that this approach has for many years continued to receive support from some areas of research, particularly genetic epidemiology. This, however, is changing and findings from genetic epidemiology are being reappraised. More importantly, the potential of molecular genetics to indicate biological systems involved in psychopathology has been recognized, and with it the potential to develop diagnostic classifications that have greater biological validity. Crucially, this will facilitate diagnostic schemes with much greater clinical utility, allowing clinicians to select treatments based on underlying pathogenesis. Recent molecular genetic findings have demonstrated very clearly the inadequacies of the dichotomous view, and highlighted the importance of better classifying cases with both psychotic and affective symptoms. In this article we discuss these issues and suggest ways forward, both immediately and for DSM-V and ICD-11. If psychiatry is to translate the opportunities offered by new research methodologies, we must move to a classificatory approach that is worthy of the 21st century.
Indexed as
Identifiers
18235858PMC2219899What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.