ArticlePancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2008
Enteral exclusion increases MAP kinase activation and cytokine production in a model of gallstone pancreatitis.
Article in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- IL-8 gene polymorphism in acute biliary and non biliary pancreatitis: probable cause of high level parameters?Annals of hepato-biliary-pancreatic surgery · 2017Article
- Role of Biomarkers in Diagnosis and Prognostic Evaluation of Acute Pancreatitis.Journal of biomarkers · 2015Review
- Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2011Article
- Nuclear factor kappa B-dependent gene transcription in cholecystokinin- and tumor necrosis factor-alpha-stimulated isolated acinar cells is regulated by p38 mitogen-activated protein kinase.American journal of surgery · 2010Article
- Dominant negative p38 mitogen-activated protein kinase expression inhibits NF-kappaB activation in AR42J cells.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2010Article
- A novel model of severe gallstone pancreatitis: murine pancreatic duct ligation results in systemic inflammation and substantial mortality.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2010Article
- Acute pancreatitis: etiology and common pathogenesis.World journal of gastroenterology · 2009Review
- Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury.American journal of surgery · 2008Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWe have previously demonstrated that enteral exclusion augments pancreatic p38 mitogen-activated protein (MAP) kinase activation and tumor necrosis factor-alpha (TNF-alpha) production after bile-pancreatic duct ligation in rats.
methodsIn the present study, we evaluated c-Jun NH(2)-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) activation, and cytokine production, in pancreata of duct-ligated rats with and without duodenal bile-pancreatic juice replacement from a donor rat. We hypothesized that enteral exclusion of bile-pancreatic juice activates stress kinases and induces cytokine production in ligation-induced acute pancreatitis.
resultsIncreased JNK and ERK activation after ligation are inhibited by bile-pancreatic juice replacement. Increases in pancreatic production of IL-1beta and IL-12 after ligation are significantly subdued by replacement. In additional in vitro studies, we show that cholecystokinin- or TNF-alpha-stimulated nuclear transcription factor kappa-B activation in AR42J cells is inhibited by dominant negative ERK2.
conclusionsOur novel findings using our Donor Rat Model indicate that bile-pancreatic juice exclusion induces MAP kinase activation and exacerbates cell stress and inflammation in this experimental model of gallstone pancreatitis. and IAP.
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