ArticleJournal of the American Society of Nephrology : JASN2008
The local and systemic inflammatory transcriptome after acute kidney injury.
Article in Journal of the American Society of Nephrology : JASN, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
150 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The mechanisms of kidney-lung interactions in chronic kidney disease-associated pulmonary diseases: A two-sample Mendelian randomization study.Renal failure · 2025Pooled it
- Novel biomarkers for predicting successful liberation of renal replacement therapy for acute kidney injury: a systematic review.Critical care (London, England) · 2025Pooled it
- Meta-analysis of molecular response of kidney to ischemia reperfusion injury for the identification of new candidate genes.BMC nephrology · 2013Pooled it
- Oridonin Protects Mice Against Cadmium-induced Kidney Injury by Inhibiting Ferroptosis via SIRT1 Regulation.Biological trace element research · 2026Article
- HMGB1/MYH9 suppresses PPARγ to induce lung injury in renal ischemia-reperfusion: protective effects of Rosiglitazone.Pediatric research · 2026Article
- Renal Ischemia-Reperfusion and Uremic Toxins Modulate the Aortic Adenosinergic Axis in Acute Kidney Injury.International journal of molecular sciences · 2026Article
- Association between acute kidney injury and delirium in critically ill patients: a retrospective cohort study using two independent databases.Critical care (London, England) · 2026Article
- The Detrimental Outcomes Associated With Kidney Delayed Graft Function Persist Beyond the Short Term.Transplantation direct · 2026Article
- The role of serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in detecting acute kidney injury in preterm neonates exposed to nephrotoxic drugs.BMC pediatrics · 2025Observational
- Ampicillin administration and the incidence of severe acute kidney injury in patients with sepsis.Renal failure · 2025Article
- Organ Crosstalk During Injury: Mechanisms of Lung-Kidney Interaction in Critical Illness.Comprehensive Physiology · 2025Review
- Prognostic Role of Kidney Disease in Newly Diagnosed Acute Myeloid Leukemia Under Venetoclax-Based Low-Intensity Therapy.Cancers · 2025Article
- Neutrophils and NETs in kidney disease.Nature reviews. Nephrology · 2025Review
- Relationship between perioperative plasma neutrophil gelatinase-associated lipocalin level and acute kidney injury after acute type A aortic dissection.Journal of thoracic disease · 2025Article
- Crosstalk between glomeruli and tubules.Nature reviews. Nephrology · 2025Review
- Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer's Disease.Journal of inflammation research · 2025Article
- Timing and risk factors associated with acute kidney injury in infants with necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Association of Acute Kidney Injury with Bronchopulmonary Dysplasia in Preterm Infants.Medeniyet medical journal · 2024Article
- Adverse effects of acute tubular injury on the glomerulus: contributing factors and mechanisms.Pediatric nephrology (Berlin, Germany) · 2024Review
- Hemorrhagic Fever with Renal Syndrome Patients Exhibit Increased Levels of Lipocalin-2, Endothelin-1 and NT-proBNP.Life (Basel, Switzerland) · 2023Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Studies in humans and animal models have demonstrated that acute kidney injury (AKI) has a significant effect on the function of extrarenal organs. The combination of AKI and lung dysfunction is associated with 80% mortality; the lung, because of its extensive capillary network, is a prime target for AKI-induced effects. The study presented here tested the hypothesis that AKI leads to a vigorous inflammatory response and produces distinct genomic signatures in the kidney and lung. In a murine model of ischemic AKI, prominent global transcriptomic changes and histologic injury in both kidney and lung tissues were identified. These changes were evident at both early (6 h) and late (36 h) timepoints after 60-min bilateral kidney ischemia and were more prominent than similar timepoints after sham surgery or 30 min of ischemia. The inflammatory transcriptome (109 genes) of both organs changed with marked similarity, including the innate immunity genes Cd14, Socs3, Saa3, Lcn2, and Il1r2. Functional genomic analysis of these genes suggested that IL-10 and IL-6 signaling was involved in the distant effects of local inflammation, and this was supported by increased serum levels of IL-10 and IL-6 after ischemia-reperfusion. In summary, this is the first comprehensive analysis of concomitant inflammation-associated transcriptional changes in the kidney and a remote organ during AKI. Functional genomic analysis identified potential mediators that connect local and systemic inflammation, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development.
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