ArticleJournal of neurophysiology2008
Summation of excitatory and inhibitory synaptic inputs by motoneurons with highly active dendrites.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Bed rest and endurance retraining alter persistent inward current estimates in young and older males.Frontiers in physiology · 2026Article
- Is soleus intrinsic motor neuron excitability contributing to motor deficits in runners with Achilles tendinopathy?European journal of applied physiology · 2025Article
- Article
- Intrinsic motoneuron properties in typical human development.The Journal of physiology · 2024Article
- The Cellular Basis for the Generation of Firing Patterns in Human Motor Units.Advances in neurobiology · 2022Article
- Concurrent Achilles tendon vibration and tibial nerve stimulation to estimate persistent inward current strength in motoneurons.European journal of translational myology · 2021Article
- Intrinsic motoneuron excitability is reduced in soleus and tibialis anterior of older adults.GeroScience · 2021Article
- Estimates of persistent inward currents are reduced in upper limb motor units of older adults.The Journal of physiology · 2021Article
- Estimates of persistent inward currents in tibialis anterior motor units during standing ramped contraction tasks in humans.Journal of neurophysiology · 2021Article
- The knowns and unknowns of neural adaptations to resistance training.European journal of applied physiology · 2021Review
- Nonlinear Input-Output Functions of Motoneurons.Physiology (Bethesda, Md.) · 2020Review
- Scaling Our World View: How Monoamines Can Put Context Into Brain Circuitry.Frontiers in cellular neuroscience · 2018Article
- Altered Neuromodulatory Drive May Contribute to Exaggerated Tonic Vibration Reflexes in Chronic Hemiparetic Stroke.Frontiers in human neuroscience · 2018Article
- The potential for understanding the synaptic organization of human motor commands via the firing patterns of motoneurons.Journal of neurophysiology · 2017Review
- Emerging Roles of Filopodia and Dendritic Spines in Motoneuron Plasticity during Development and Disease.Neural plasticity · 2016Review
- Gain control mechanisms in spinal motoneurons.Frontiers in neural circuits · 2014Article
- Motoneuron intrinsic properties, but not their receptive fields, recover in chronic spinal injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Models of passive and active dendrite motoneuron pools and their differences in muscle force control.Journal of computational neuroscience · 2012Article
- Synchronous and asynchronous electrically evoked motor activities during wind-up stimulation are differentially modulated following an acute spinal transection.Journal of neurophysiology · 2012Article
- Push-pull control of motor output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
Corrections and comments
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3 authors.
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Abstract
We investigated summation of steady excitatory and inhibitory inputs in spinal motoneurons using an in vivo preparation, the decerebrate cat, in which neuromodulatory input from the brain stem facilitated a strong persistent inward current (PIC) in dendritic regions. This dendritic PIC amplified both excitatory and inhibitory synaptic currents two- to threefold, but within different voltage ranges. Amplification of excitatory synaptic current peaked at voltage-clamp holding potentials near spike threshold (about -55 to -50 mV), whereas amplification of inhibitory current peaked at significantly more depolarized levels (about -45 to -40 mV). Thus the linear sum of excitatory and inhibitory currents tended to vary from net excitatory to net inhibitory as holding potential was depolarized. The actual summed currents, however, diverged from the predicted linear currents. At the peak of excitation, summation averaged about 15% sublinear (actual sum was less positive than the linear sum). In contrast, at the peak of inhibition, summation averaged about 18% supralinear (actual more positive than linear). Moreover, these nonlinear effects were substantially larger in cells where the variation from peak excitation to peak inhibition for linear summation was larger. When descending neuromodulatory input was eliminated by acute spinalization, PIC amplification was not observed and summation tended to be either sublinear or approximately linear, depending on input source. Overall, in cells with strong PICs, nonlinear summation of excitation and inhibition does occur, but this nonlinearity results in a more consistent relationship between membrane potential and the summed excitatory and inhibitory current.
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