ArticleJournal of neurophysiology2008
Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptors.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 88 citations in OpenAlex.
- Article
- A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation.Cell metabolism · 2025Article
- A key role of PIEZO2 mechanosensitive ion channel in adipose sensory innervation.bioRxiv : the preprint server for biology · 2024Article
- Pain and itch coding mechanisms of polymodal sensory neurons.Cell reports · 2023Article
- Sensory neuron-specific long noncoding RNA in small non-peptidergic dorsal root ganglion neurons selectively impairs nerve injury-induced mechanical hypersensitivity.Life sciences · 2023Article
- DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.Cell · 2023Article
- G protein-coupled receptors as targets for transformative neuropsychiatric therapeutics.American journal of physiology. Cell physiology · 2023Review
- The structure, function, and pharmacology of MRGPRs.Trends in pharmacological sciences · 2023Review
- Computational design of peptides to target NaeLife · 2022Article
- Mechanisms of bone pain: Progress in research from bench to bedside.Bone research · 2022Review
- Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor function.The FEBS journal · 2022Article
- Peripheral Mechanisms of Itch.The Journal of investigative dermatology · 2022Review
- Keratinocyte Biomarkers Distinguish Painful Diabetic Peripheral Neuropathy Patients and Correlate With Topical Lidocaine Responsiveness.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Post-Burn Pruritus.International journal of molecular sciences · 2020Review
- Mechanisms and Management of Itch in Dry Skin.Acta dermato-venereologica · 2020Review
- Nociceptor subtypes and their incidence in rat lumbar dorsal root ganglia (DRGs): focussing on C-polymodal nociceptors, Aβ-nociceptors, moderate pressure receptors and their receptive field depths.Current opinion in physiology · 2019Review
- Development of a Mouse Pain Scale Using Sub-second Behavioral Mapping and Statistical Modeling.Cell reports · 2019Article
- Expression and function of the ectopic olfactory receptor OR10G7 in patients with atopic dermatitis.The Journal of allergy and clinical immunology · 2019Article
- Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons.Handbook of experimental pharmacology · 2018Review
- Morphological and functional diversity of first-order somatosensory neurons.Biophysical reviews · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Sensory neurons expressing the Mrgprd receptor are known to innervate the outermost living layer of the epidermis, the stratum granulosum. The sensory modality that these neurons signal and the stimulus that they respond to are not established, although immunocytochemical data suggest they could be nonpeptidergic nociceptors. Using patch clamp of dissociated mouse dorsal root ganglion (DRG) neurons, the present study demonstrates that Mrgprd+ neurons have several properties typical of nociceptors: long-duration action potentials, TTX-resistant Na(+) current, and Ca(2+) currents that are inhibited by mu opioids. Remarkably, Mrgprd+ neurons respond almost exclusively to extracellular ATP with currents similar to homomeric P2X3 receptors. They show little or no sensitivity to other putative nociceptive agonists, including capsaicin, cinnamaldehyde, menthol, pH 6.0, or glutamate. These properties, together with selective innervation of the stratum granulosum, indicate that Mrgprd+ neurons are nociceptors in the outer epidermis and may respond indirectly to external stimuli by detecting ATP release in the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.