ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Differential tonic GABA conductances in striatal medium spiny neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 169 citations in OpenAlex.
- Application of Machine Learning Models to Identify Differences in Neural Electrophysiological Properties Across Estrous Cycle Phases.Neuroinformatics · 2026Article
- Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors.Pharmaceuticals (Basel, Switzerland) · 2025Review
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- GABAiScience · 2025Article
- Different development patterns of reward behaviors induced by ketamine and JWH-018 in striatal GAD67 knockdown mice.Journal of veterinary science · 2024Article
- GABA co-released from striatal dopamine axons dampens phasic dopamine release through autoregulatory GABACell reports · 2024Article
- GABAergic regulation of striatal spiny projection neurons depends upon their activity state.PLoS biology · 2024Article
- Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- GABA tone regulation and its cognitive functions in the brain.Nature reviews. Neuroscience · 2023Review
- Memantine Use and Cognitive Decline in Huntington's Disease: An Enroll-HD Study.Movement disorders clinical practice · 2023Article
- The ethanol inhibition of basolateral amygdala neuron spiking is mediated by a γ-aminobutyric acid type A-mediated tonic current.Alcoholism, clinical and experimental research · 2022Article
- Generation of Astrocyte-Specific MAOB Conditional Knockout Mouse with Minimal Tonic GABA Inhibition.Experimental neurobiology · 2022Article
- The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Combining electrophysiology and optogenetics for functional screening of pyramidal neurons in the mouse prefrontal cortex.STAR protocols · 2021Article
- Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.Cells · 2021Review
- Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex.Nature communications · 2020Article
- GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model.Nature communications · 2020Article
- The impact of manganese on neurotransmitter systems.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2020Review
- Article
- Tonic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Medium spiny neurons (MSNs) provide the principal output for the dorsal striatum. Those that express dopamine D2 receptors (D2+) project to the globus pallidus external and are thought to inhibit movement, whereas those that express dopamine D1 receptors (D1+) project to the substantia nigra pars reticulata and are thought to facilitate movement. Whole-cell and outside-out patch recordings in slices from bacterial artificial chromosome transgenic mice examined the role of GABA(A) receptor-mediated currents in dopamine receptor D1+ striatonigral and D2+ striatopallidal MSNs. Although inhibitory synaptic currents were similar between the two neuronal populations, D2+ MSNs showed greater GABA(A) receptor-mediated tonic currents. TTX application abolished the tonic current to a similar extent as GABA(A) antagonists, suggesting a synaptic origin of the ambient GABA. Low GABA concentrations produced larger whole-cell responses and longer GABA channel openings in D2+ than in D1+ MSNs. Recordings from MSNs in alpha1-/- mice and pharmacological analysis of tonic currents suggested greater expression of alpha5-containing GABA(A) receptors in D2+ than in D1+ MSNs. As a number of disorders such as Parkinson's disease, Huntington's chorea, and tardive dyskinesia arise from an imbalance between these two pathways, the GABA(A) receptors responsible for tonic currents in D2+ MSNs may be a potential target for therapeutic intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.