ArticleMolecular biology of the cell2008
Sep7 is essential to modify septin ring dynamics and inhibit cell separation during Candida albicans hyphal growth.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 76 citations in OpenAlex.
- Profound cell wall remodeling inMicrobiology spectrum · 2026Article
- Signaling Pathways Regulating Dimorphism in Medically Relevant Fungal Species.Pathogens (Basel, Switzerland) · 2025Review
- Reprogramming inInternational journal of molecular sciences · 2023Article
- Morphogenic plasticity: the pathogenic attribute of Candida albicans.Current genetics · 2023Review
- Integrative multi-omics profiling reveals cAMP-independent mechanisms regulating hyphal morphogenesis in Candida albicans.PLoS pathogens · 2021Article
- From Jekyll to Hyde: The Yeast-Hyphal Transition ofPathogens (Basel, Switzerland) · 2021Review
- Functional connections between cell cycle and proteostasis in the regulation of Candida albicans morphogenesis.Cell reports · 2021Review
- The ESCRT System Plays an Important Role in the Germination in Candida albicans by Regulating the Expression of Hyphal-Specific Genes and the Localization of Polarity-Related Proteins.Mycopathologia · 2020Article
- Review
- Article
- Temporal regulation of morphogenetic events in Saccharomyces cerevisiae.Molecular biology of the cell · 2018Article
- Candida albicans Cdc15 is essential for mitotic exit and cytokinesis.Scientific reports · 2018Article
- The anillin-related Int1 protein and the Sep7 septin collaborate to maintain cellular ploidy in Candida albicans.Scientific reports · 2018Article
- Candida albicans Hyphae: From Growth Initiation to Invasion.Journal of fungi (Basel, Switzerland) · 2018Review
- An Update onFrontiers in microbiology · 2017Review
- Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures.Microbiology (Reading, England) · 2016Review
- The Nim1 kinase Gin4 has distinct domains crucial for septin assembly, phospholipid binding and mitotic exit.Journal of cell science · 2016Article
- Hgc1-Cdc28-how much does a single protein kinase do in the regulation of hyphal development in Candida albicans?Journal of microbiology (Seoul, Korea) · 2016Review
- Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans.Journal of microbiology (Seoul, Korea) · 2016Review
- Rho1- and Pkc1-dependent phosphorylation of the F-BAR protein Syp1 contributes to septin ring assembly.Molecular biology of the cell · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When Candida albicans yeast cells receive the appropriate stimulus, they switch to hyphal growth, characterized by continuous apical elongation and the inhibition of cell separation. The molecular basis of this inhibition is poorly known, despite its crucial importance for hyphal development. In C. albicans, septins are important for hypha formation and virulence. Here, we used fluorescence recovery after photobleaching analysis to characterize the dynamics of septin rings during yeast and hyphal growth. On hyphal induction, septin rings are converted to a hyphal-specific state, characterized by the presence of a frozen core formed by Sep7/Shs1, Cdc3 and Cdc12, whereas Cdc10 is highly dynamic and oscillates between the ring and the cytoplasm. Conversion of septin rings to the hyphal-specific state inhibits the translocation of Cdc14 phosphatase, which controls cell separation, to the hyphal septum. Modification of septin ring dynamics during hyphal growth is dependent on Sep7 and the hyphal-specific cyclin Hgc1, which partially controls Sep7 phosphorylation status and protein levels. Our results reveal a link between the cell cycle machinery and septin cytoskeleton dynamics, which inhibits cell separation in the filaments and is essential for hyphal morphogenesis.
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