ArticleBiophysical journal2008
Fluctuations of the red blood cell membrane: relation to mechanical properties and lack of ATP dependence.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 143 citations in OpenAlex.
- Temperature as a Regulator of Red Blood Cell Fate: From Membrane Dynamics to Cellular Clearance.Medical sciences (Basel, Switzerland) · 2026Review
- Multi-scale simulation of red blood cell trauma in large-scale high-shear flows after Norwood operation.Computer methods and programs in biomedicine · 2025Article
- Effective cell membrane tension protects red blood cells against malaria invasion.PLoS computational biology · 2023Article
- Effects of membrane viscoelasticity on the red blood cell dynamics in a microcapillary.Biophysical journal · 2023Article
- Article
- Biophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.Frontiers in cellular and infection microbiology · 2022Review
- Structural and mechanical properties of the red blood cell's cytoplasmic membrane seen through the lens of biophysics.Frontiers in physiology · 2022Review
- Article
- Doppler imaging detects bacterial infection of living tissue.Communications biology · 2021Article
- The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells.Science advances · 2021Article
- Differential dielectroscopic data on the relation of erythrocyte membrane skeleton to erythrocyte deformability and flicker.European biophysics journal : EBJ · 2021Article
- Dynamic and reversible shape response of red blood cells in synthetic liquid crystals.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Flow-induced segregation and dynamics of red blood cells in sickle cell disease.Physical review fluids · 2020Article
- Non-uniform distribution of myosin-mediated forces governs red blood cell membrane curvature through tension modulation.PLoS computational biology · 2020Article
- Quantitative absorption imaging of red blood cells to determine physical and mechanical properties.RSC advances · 2020Article
- Quantitative analysis of three-dimensional morphology and membrane dynamics of red blood cells during temperature elevation.Scientific reports · 2019Article
- Measurements on ATP induced cellular fluctuations using real-time dual view transport of intensity phase microscopy.Biomedical optics express · 2019Article
- Dynamics of deformable straight and curved prolate capsules in simple shear flow.Physical review fluids · 2019Article
- Doppler fluctuation spectroscopy of intracellular dynamics in living tissue.Journal of the Optical Society of America. A, Optics, image science, and vision · 2019Article
- A Model of Piezo1-Based Regulation of Red Blood Cell Volume.Biophysical journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
We have analyzed the fluctuations of the red blood cell membrane in both the temporal ((omega(s(-1))) and spatial (q(m(-1))) frequency domains. The cells were examined over a range of osmolarities leading to cell volumes from 50% to 170% of that in the isotonic state. The fluctuations of the isotonic cell showed an approximately q(-3)-dependence, indicative of a motion dominated by bending, with an inferred bending modulus of approximately 9 x 10(-19) J. When the cells were osmotically swollen to just below the point of lysis (166% of physiological volume), a q(-1)-dependence of the fluctuations supervened, implying that the motion was now dominated by membrane tension; estimated as approximately 1.3 x 10(-4) nm(-1). When, on the other hand, the cells were osmotically dehydrated, the fluctuation amplitude progressively decreased. This was caused by a rise in internal viscosity, as shown by measurements on resealed ghosts containing a reduced hemoglobin concentration, which displayed no such effect. We examined, in addition, cells depleted of ATP, before the onset of echinocytosis, and could observe no change in fluctuation amplitude. We conclude that the membrane fluctuations of the red cell are governed by bending modulus, membrane tension, and cytosolic viscosity, with little or no dependence on the presence or absence of ATP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.