ArticleBiophysical journal2008
Differential modulation of membrane structure and fluctuations by plant sterols and cholesterol.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Stigmasterol-Based EGCG Liposomes Reduce Nε-(carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) in a Model System and Cookies.Foods (Basel, Switzerland) · 2026Article
- Plant-derived extracellular vesicles for drug delivery: current and future.Regenerative biomaterials · 2026Review
- Stigmasterol: An Enigmatic Plant Stress Sterol with Versatile Functions.International journal of molecular sciences · 2024Review
- Characterization of Subcellular Dynamics of Sterol Methyltransferases Clarifies Defective Cell Division inBiomolecules · 2024Article
- Small-Angle X-ray Scattering (SAXS) Used for the Identification of Nicomorphine Polymorphic Changes at the Early Stage to Avoid Varied Stability and Possible Side Effects.Pharmaceuticals (Basel, Switzerland) · 2024Article
- The microdomains (rafts) of plasmalemma in the protection of the plant cell under oxidative stress.Protoplasma · 2023Article
- Article
- Article
- Acylglycerols of Myristic Acid as New Candidates for Effective Stigmasterol Delivery-Design, Synthesis, and the Influence on Physicochemical Properties of Liposomes.Molecules (Basel, Switzerland) · 2022Article
- Peptide-Folding Triggered Phase Separation and Lipid Membrane Destabilization in Cholesterol-Rich Lipid Vesicles.Bioconjugate chemistry · 2022Article
- Phytosterol metabolism in plant positive-strand RNA virus replication.Plant cell reports · 2022Review
- Sitosterol and glucosylceramide cooperative transversal and lateral uneven distribution in plant membranes.Scientific reports · 2021Article
- Comparing the stability of retinol in liposomes with cholesterol, β-sitosterol, and stigmasterol.Food science and biotechnology · 2021Article
- Changes in the Plant β-Sitosterol/Stigmasterol Ratio Caused by the Plant Parasitic NematodePlants (Basel, Switzerland) · 2021Article
- Impact of Quercetin Encapsulation with Added Phytosterols on Bilayer Membrane and Photothermal-Alteration of Novel Mixed Soy Lecithin-Based Liposome.Nanomaterials (Basel, Switzerland) · 2020Article
- Non-detergent Isolation of Membrane Structures from Beet Plasmalemma and Tonoplast Having Lipid Composition Characteristic of Rafts.The Journal of membrane biology · 2020Article
- Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA.Nature communications · 2020Article
- Organization and dynamics of functional plant membrane microdomains.Cellular and molecular life sciences : CMLS · 2020Review
- The Impact of Solvent Selection: Strategies to Guide the Manufacturing of Liposomes Using Microfluidics.Pharmaceutics · 2019Article
- Caveolin-1 Endows Order in Cholesterol-Rich Detergent Resistant Membranes.Biomolecules · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the concentration and temperature dependent influence of cholesterol, stigmasterol, and sitosterol on the global structure and the bending fluctuations of fluid dimyristoyl phosphatidylcholine and palmitoyl oleoyl phosphatidylcholine bilayers applying small-angle x-ray scattering, as well as dilatometry and ultrasound velocimetry. Independent of the lipid matrix, cholesterol was found to be most efficient in modulating bilayer thickness and elasticity, followed by sitosterol and stigmasterol. This can be attributed to the additional ethyl groups and double bond at the C(17) alkyl side-chain of the two plant sterols. Hence, it seems that some flexibility of the sterol hydrocarbon chain is needed to accommodate within the lipid bilayer. In addition, we did not observe two populations of membranes within the putative liquid-ordered/liquid-disordered phase coexistence regime of binary sterol/lipid mixtures. Instead, the diffraction patterns could be interpreted in terms of a uniform phase. This lends further support to the idea of compositional fluctuations of unstable sterol rich domains recently brought up by fluorescence microscopy experiments, which contrasts the formation of stable domains within the miscibility gap of binary lipid/sterol mixtures.
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Registered trials
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