ArticleNeurobiology of learning and memory2008
Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus.
Article in Neurobiology of learning and memory, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Transcriptional signatures of brain aging and Alzheimer's disease: What are our rodent models telling us?Behavioural brain research · 2017Pooled it
- Hippocampal gene expression meta-analysis identifies aging and age-associated spatial learning impairment (ASLI) genes and pathways.PloS one · 2013Pooled it
- Cognitive rejuvenation in old rats by hippocampal OSKM gene therapy.GeroScience · 2025Article
- Genetic variants in the TAC1 transcriptional regulatory region affect on trainability and excitability levels in Belgian Malinois dogs.Veterinary medicine and science · 2024Article
- Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids.Communications biology · 2021Article
- Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Long-Term Intranasal Insulin Aspart: A Profile of Gene Expression, Memory, and Insulin Receptors in Aged F344 Rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- White Matter is the Predilection Site of Late-Delayed Radiation-Induced Brain Injury in Non-Human Primates.Radiation research · 2019Article
- Genome-Wide Temporal Expression Profiling inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Gene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment.Frontiers in systems neuroscience · 2017Article
- Age-related changes in Egr1 transcription and DNA methylation within the hippocampus.Hippocampus · 2016Article
- Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor κB-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Decreased Npas4 and Arc mRNA Levels in the Hippocampus of Aged Memory-Impaired Wild-Type But Not Memory Preserved 11β-HSD1 Deficient Mice.Journal of neuroendocrinology · 2016Article
- Learning impairments identified early in life are predictive of future impairments associated with aging.Behavioural brain research · 2015Article
- Molecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy.Neurobiology of disease · 2015Article
- Protein expression profiles characterize distinct features of mouse cerebral cortices at different developmental stages.PloS one · 2015Article
- Article
- Social stress increases expression of hemoglobin genes in mouse prefrontal cortex.BMC neuroscience · 2014Article
- Identification of learning and memory genes in canine; promoter investigation and determining the selective pressure.Molecular biology reports · 2014Article
- Neurotoxic saboteurs: straws that break the hippo's (hippocampus) back drive cognitive impairment and Alzheimer's Disease.Neurotoxicity research · 2013Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We have previously described the transcriptional changes that occur in the hippocampal CA1 field of aged rats following a Morris Water Maze (MWM) training paradigm. In this report we proceed with the analysis of the dentate region from the same animals. Animals were first identified as age learning-impaired or age-superior learners when compared to young rats based on their performance in the MWM. Messenger RNA was isolated from the dentate gyrus of each animal to interrogate Affymetrix RAE 230A rat genome microarrays. Microarray profiling identified 1129 genes that were differentially expressed between aged and young rats as a result of aging, and independent of their behavioral training (p<0.005). We applied Ingenuity Pathway Analysis (IPA) algorithms to identify the significant biological processes underlying age-related changes in the dentate gyrus. The most significant functions, as calculated by IPA, included cell movement, cell growth and proliferation, nervous system development and function, cellular assembly and organization, cell morphology and cell death. These significant processes are consistent with age-related changes in neurogenesis, and the neurogenic markers were generally found to be downregulated in senescent animals. In addition, statistical analysis of the different experimental groups of aged animals recognized 85 genes (p<0.005) that were different in the dentate gyrus of aged rats that had learned the MWM when compared to learning impaired and a number of controls for stress, exercise and non-spatial learning. The list of learning-related genes expressed in the dentate adds to the set of genes we previously described in the CA1 region. This long list of genes constitutes a starting tool to elucidating the molecular pathways involved in learning and memory formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.