ArticlePharmacology, biochemistry, and behavior2008
The melanocortin antagonist AgRP (83-132) increases appetitive responding for a fat, but not a carbohydrate, reinforcer.
Article in Pharmacology, biochemistry, and behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- A gene-diet interaction controlling relative intake of dietary carbohydrates and fats.Molecular metabolism · 2022Article
- Review
- Early life high-fat diet exposure maintains glucose tolerance and insulin sensitivity with a fatty liver and small brain size in the adult offspring.Nutrition research (New York, N.Y.) · 2019Article
- Altered sucrose self-administration following injection of melanocortin receptor agonists and antagonists into the ventral tegmental area.Psychopharmacology · 2017Article
- Divergent effects of central melanocortin signalling on fat and sucrose preference in humans.Nature communications · 2016Article
- Melanocortin 4 Receptor and Dopamine D2 Receptor Expression in Brain Areas Involved in Food Intake.Endocrinology and metabolism (Seoul, Korea) · 2015Article
- Eating behavior in frontotemporal dementia: Peripheral hormones vs hypothalamic pathology.Neurology · 2015Article
- Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.Frontiers in behavioral neuroscience · 2015Article
- Decreased consumption of rewarding sucrose solutions after injection of melanocortins into the ventral tegmental area of rats.Psychopharmacology · 2015Article
- Article
- The hormonal signature of energy deficit: Increasing the value of food reward.Molecular metabolism · 2013Review
- Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The effect of vertical sleeve gastrectomy on food choice in rats.International journal of obesity (2005) · 2013Article
- Article
- Article
- Neural and metabolic regulation of macronutrient intake and selection.The Proceedings of the Nutrition Society · 2012Review
- Pre- and postnatal calorie restriction perturbs early hypothalamic neuropeptide and energy balance.Journal of neuroscience research · 2012Article
- Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.Obesity (Silver Spring, Md.) · 2012Article
- Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression.Addiction biology · 2012Article
- Central melanocortins modulate mesocorticolimbic activity and food seeking behavior in the rat.Physiology & behavior · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Consumption of a diet high in fat is a risk factor for a number of health problems, including obesity, type 2 diabetes and cardiovascular disease. Considerable pharmacological, genetic, and molecular evidence suggests that the hypothalamic melanocortin system plays a critical role in the control of food intake and body weight and, specifically, in fat ingestion. Administration of a melanocortin antagonist, agouti-related peptide (AgRP) (83-132) selectively increases intake of pure fat and high-fat mixed diets. Here, we examined possible mechanisms for this fat-specific effect of AgRP (83-132). In Experiment 1, we determined that intracerebroventricular administration of AgRP (83-132) selectively increased operant responding for a peanut oil, but not a sucrose, reinforcer when tested under a progressive ratio schedule. Experiment 2 employed a Pavlovian conditioning paradigm, in which icv AgRP enhanced appetitive responding toward stimuli that had previously been paired with peanut oil and reduced responding toward stimuli previously paired with sucrose, in the absence of consumption of either macronutrient. Finally, in Experiment 3, we tested the hypothesis that the MC system acts in anticipation of a fat consumption and found that hypothalamic AgRP mRNA was slightly, though not significantly, elevated in an environment predicting fat availability relative to one predicting carbohydrate availability. Collectively, these data indicate that, in addition to increasing free intake of dietary fats, AgRP (83-132) promotes responding for the opportunity to consume a fat reinforcer, as well as appetitive responding to fat-paired stimuli in the absence of ingestive stimulation. These results suggest a possible role for AgRP in the increased fat intake associated with obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.