ArticlePhysiology & behavior2008
Factors regulating vagal sensory development: potential role in obesities of developmental origin.
Article in Physiology & behavior, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Upregulation of proBDNF in the Mesenteric Lymph Nodes in Septic Mice.Neurotoxicity research · 2019Article
- Stimulation of synthesis and release of brain-derived neurotropic factor from intestinal smooth muscle cells by substance P and pituitary adenylate cyclase-activating peptide.Neurogastroenterology and motility · 2015Article
- Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity.The Journal of physiology · 2015Article
- Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Vagal afferent controls of feeding: a possible role for gastrointestinal BDNF.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2013Review
- Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice.Neuroscience · 2013Article
- Early postnatal overnutrition: potential roles of gastrointestinal vagal afferents and brain-derived neurotrophic factor.Physiology & behavior · 2012Review
- Development of the vagal innervation of the gut: steering the wandering nerve.Neurogastroenterology and motility · 2011Review
- Molecular development of the extrinsic sensory innervation of the gastrointestinal tract.Autonomic neuroscience : basic & clinical · 2011Review
- Meal parameters and vagal gastrointestinal afferents in mice that experienced early postnatal overnutrition.Physiology & behavior · 2010Article
- Mice deficient in brain-derived neurotrophic factor have altered development of gastric vagal sensory innervation.The Journal of comparative neurology · 2010Article
- Alimentary Epigenetics: A Developmental Psychobiological Systems View of the Perception of Hunger, Thirst and Satiety.Developmental review : DR · 2008Article
- Purdue Ingestive Behavior Research Center symposium 2007: influences on eating and body weight over the lifespan--childhood and adolescence.Physiology & behavior · 2008Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Contributors to increased obesity in children may include perinatal under- or overnutrition. Humans and rodents raised under these conditions develop obesity, which like obesities of other etiologies has been associated with increased meal size. Since vagal sensory innervation of the gastrointestinal (GI) tract transmits satiation signals that regulate meal size, one mechanism through which abnormal perinatal nutrition could increase meal size is by altering vagal development, possibly by causing changes in the expression of factors that control it. Therefore, we have begun to characterize development of vagal innervation of the GI tract and the expression patterns and functions of the genes involved in this process. Important events in development of mouse vagal GI innervation occurred between midgestation and the second postnatal week, suggesting they could be vulnerable to effects of abnormal nutrition pre- or postnatally. One gene investigated was brain- derived neurotrophic factor (BDNF), which regulates survival of a subpopulation of vagal sensory neurons. BDNF was expressed in some developing stomach wall tissues innervated by vagal afferents. At birth, mice deficient in BDNF exhibited a 50% reduction of putative intraganglionic laminar ending mechanoreceptor precursors, and a 50% increase in axons that had exited fiber bundles. Additionally, BDNF was required for patterning of individual axons and fiber bundles in the antrum and differentiation of intramuscular array mechanoreceptors in the forestomach. It will be important to determine whether abnormal perinatal environments alter development of vagal sensory innervation of the GI tract, involving effects on expression of BDNF, or other factors regulating vagal development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.