Evidence map›Paper›PMID 18234145›Full record

ArticleInternational psychogeriatrics2008

Twelve-year depressive symptom trajectories and their predictors in a community sample of older adults.

Carmen Andreescu, Chou-Chung H Chang, Benoit H Mulsant, Mary Ganguli

Open access · diamondAbstract read
In one paragraph

Article in International psychogeriatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effects of Problem-Solving Therapy and Clinical Case Management on Disability in Low-Income Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2015
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  15. Trajectories of Depressive Symptoms Experienced by Older People: Effects of Time, Hurricane Sandy, and the Great Recession.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021
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  18. Depression Symptoms Declining Among Older Adults: Birth Cohort Analyses From the Rust Belt.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Carmen AndreescuDepartment of Psychiatry. University of Pittsburgh School of Medicine, Pittsburgh, USA. andreescuc@upmc.edu
Chou-Chung H Chang
Benoit H Mulsant
Mary Ganguli
University of Pittsburgh · USCentre for Addiction and Mental Health · CA

Funding

EPIDEMIOLOGY OF DEMENTIA: A PROSPECTIVE COMMUNITY STUDYR01AG007562 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GANGULI, MARY · 1989 to 2002
$2.0M
Outcomes and Predictors in Mild Cognitive ImpairmentK24AG022035 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GANGULI, MARY · 2003 to 2012
$1.3M
Complex Trials for Severe Geriatric Mood DisordersK24MH069430 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MULSANT, BENOIT H · 2004 to 2008
$601k
A Generalized Model for Post-transplant SurvivalK25DK059928 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHANG, CHUNG-CHOU HO · 2001 to 2005
$576k
NIA NIH HHS K24 AG022035NIA NIH HHS R01 AG007562NIA NIH HHS R01 AG07562NIDDK NIH HHS K25 DK059928NIMH NIH HHS K24 MH069430
6 · The paper itself

Abstract

introductionThe aim of this study is to understand the long-term course and outcomes of depressive symptoms among older adults in the community by examining trajectories of depressive symptoms over time and identifying profiles of depressive symptoms predicting different trajectories.

methodWe measured depressive symptoms biennially for up to 12 years, using the modified Center for Epidemiological Studies-Depression (mCES-D) scale, in 1260 community-based adults aged 65+ years. We determined latent trajectories of total mCES-D scores over time. We identified symptom profiles based on subgroups of baseline depressive symptoms derived from factor analysis, and examined their associations with the different trajectories.

resultsSix trajectories were identified. Two had one or no depressive symptoms at baseline and flat trajectories during follow-up. Two began with low baseline symptom scores and then diverged; female sex and functional disability were associated with future increases in depressive symptoms. Two trajectories began with high baseline scores but had different slopes: the higher trajectory was associated with medical burden, higher overall baseline score, and higher baseline scores on symptom profiles including low self-esteem, interpersonal difficulties, neurovegetative symptoms, and anhedonia. Mortality was higher among those in the higher trajectories.

conclusionsIn the community at large, those with minimal depressive symptoms are more likely to experience future increases in symptoms if they are women and have functional disability. Among those with higher current symptom levels, depression is more likely to persist over time in individuals who have greater medical burden and specific depressive symptoms.

Indexed as

AgedCommunity Mental Health ServicesDepressionFemaleHumansIncidenceMalePredictive Value of TestsSeverity of Illness Index

Identifiers

PMID18234145
PMCPMC2743537
OpenAlexW2023036351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.